Complex I model#
Comparing Gauthier, Markevich, and simplified complex I models.
using ModelingToolkit
using NonlinearSolve
using OrdinaryDiffEq
using SteadyStateDiffEq
using Plots
using NaNMath
using DisplayAs: PNG
using ECMEDox: iVT, mV, μM, mM, Molar, Hz
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Candidates#
Gauthier 2012#
Gauthier 2012 7-state QSSA model
function c1_gauthier(; name=:c1gauthier,
Q_n=1800μM, QH2_n=200μM, nad=500μM, nadh=500μM,
dpsi=150mV, O2=6μM, sox_m=0.01μM,
h_i=exp10(-7) * Molar, h_m=exp10(-7.6) * Molar,
C1_INHIB=1)
@independent_variables t
D = Differential(t)
@parameters begin
ET_C1 = 8.85mM ## Activity of complex I
dpsi_B_C1 = 50mV ## Phase boundary potential
# Transition rates
K12_C1 = 6.3396E11Hz / mM^2
K21_C1 = 5Hz
K56_C1 = 100Hz
K65_C1 = 2.5119E13Hz / mM^2
K61_C1 = 1e7Hz
K16_C1 = 130Hz
K23_C1 = 3886.7Hz / sqrt(mM)
K32_C1 = 9.1295e6Hz
K34_C1 = 639.1364Hz
K43_C1 = 3.2882Hz / sqrt(mM)
K47_C1 = 1.5962E7Hz / mM
K74_C1 = 65.2227Hz
K75_C1 = 24615Hz
K57_C1 = 1166.7Hz / sqrt(mM)
K42_C1 = 6.0318Hz / mM
Em_O2_SOX = -160mV ## O2/Superoxide redox potential
Em_FMNH2_FMNH = -375mV ## FMNH/FMNH2 redox potential
rKEQ_ROS_C1 = exp(iVT * (Em_FMNH2_FMNH - Em_O2_SOX))
end
@variables begin
C1_1(t)
C1_2(t)
C1_3(t)
C1_4(t)
C1_5(t)
C1_6(t)
C1_7(t)
wC1_1(t)
wC1_2(t)
wC1_3(t)
wC1_4(t)
wC1_5(t)
wC1_6(t)
wC1_7(t)
vQC1(t)
vNADHC1(t)
vROSC1(t)
vHresC1(t)
TNC1(t) ## Turnover number
end
fv = exp(iVT * (dpsi - dpsi_B_C1))
# State transition rates
a12 = K12_C1 * h_m^2
a21 = K21_C1
a65 = K65_C1 * h_i^2
a56 = K56_C1
a61 = K61_C1 / fv
a16 = K16_C1 * fv
a23 = K23_C1 * NaNMath.sqrt(nadh)
a32 = K32_C1
a34 = K34_C1
a43 = K43_C1 * NaNMath.sqrt(nad)
a47 = C1_INHIB * K47_C1 * NaNMath.sqrt(Q_n * h_m)
a74 = K74_C1
a57 = C1_INHIB * K57_C1 * NaNMath.sqrt(QH2_n)
a75 = K75_C1
a42 = K42_C1 * O2
a24 = K42_C1 * rKEQ_ROS_C1 * sox_m
# KA pattern
w1 = a21 * a32 * a42 * a56 * a61 * a74 + a21 * a32 * a42 * a56 * a61 * a75 + a21 * a32 * a42 * a57 * a61 * a74 + a21 * a32 * a42 * a57 * a65 * a74 + a21 * a32 * a43 * a56 * a61 * a74 + a21 * a32 * a43 * a56 * a61 * a75 + a21 * a32 * a43 * a57 * a61 * a74 + a21 * a32 * a43 * a57 * a65 * a74 + a21 * a32 * a47 * a56 * a61 * a75 + a21 * a34 * a42 * a56 * a61 * a74 + a21 * a34 * a42 * a56 * a61 * a75 + a21 * a34 * a42 * a57 * a61 * a74 + a21 * a34 * a42 * a57 * a65 * a74 + a21 * a34 * a47 * a56 * a61 * a75 + a23 * a34 * a47 * a56 * a61 * a75 + a24 * a32 * a47 * a56 * a61 * a75 + a24 * a34 * a47 * a56 * a61 * a75
w2 = a12 * a32 * a42 * a56 * a61 * a74 + a12 * a32 * a42 * a56 * a61 * a75 + a12 * a32 * a42 * a57 * a61 * a74 + a12 * a32 * a42 * a57 * a65 * a74 + a12 * a32 * a43 * a56 * a61 * a74 + a12 * a32 * a43 * a56 * a61 * a75 + a12 * a32 * a43 * a57 * a61 * a74 + a12 * a32 * a43 * a57 * a65 * a74 + a12 * a32 * a47 * a56 * a61 * a75 + a12 * a34 * a42 * a56 * a61 * a74 + a12 * a34 * a42 * a56 * a61 * a75 + a12 * a34 * a42 * a57 * a61 * a74 + a12 * a34 * a42 * a57 * a65 * a74 + a12 * a34 * a47 * a56 * a61 * a75 + a16 * a32 * a42 * a57 * a65 * a74 + a16 * a32 * a43 * a57 * a65 * a74 + a16 * a34 * a42 * a57 * a65 * a74
w3 = a12 * a23 * a42 * a56 * a61 * a74 + a12 * a23 * a42 * a56 * a61 * a75 + a12 * a23 * a42 * a57 * a61 * a74 + a12 * a23 * a42 * a57 * a65 * a74 + a12 * a23 * a43 * a56 * a61 * a74 + a12 * a23 * a43 * a56 * a61 * a75 + a12 * a23 * a43 * a57 * a61 * a74 + a12 * a23 * a43 * a57 * a65 * a74 + a12 * a23 * a47 * a56 * a61 * a75 + a12 * a24 * a43 * a56 * a61 * a74 + a12 * a24 * a43 * a56 * a61 * a75 + a12 * a24 * a43 * a57 * a61 * a74 + a12 * a24 * a43 * a57 * a65 * a74 + a16 * a21 * a43 * a57 * a65 * a74 + a16 * a23 * a42 * a57 * a65 * a74 + a16 * a23 * a43 * a57 * a65 * a74 + a16 * a24 * a43 * a57 * a65 * a74
w4 = a12 * a23 * a34 * a56 * a61 * a74 + a12 * a23 * a34 * a56 * a61 * a75 + a12 * a23 * a34 * a57 * a61 * a74 + a12 * a23 * a34 * a57 * a65 * a74 + a12 * a24 * a32 * a56 * a61 * a74 + a12 * a24 * a32 * a56 * a61 * a75 + a12 * a24 * a32 * a57 * a61 * a74 + a12 * a24 * a32 * a57 * a65 * a74 + a12 * a24 * a34 * a56 * a61 * a74 + a12 * a24 * a34 * a56 * a61 * a75 + a12 * a24 * a34 * a57 * a61 * a74 + a12 * a24 * a34 * a57 * a65 * a74 + a16 * a21 * a32 * a57 * a65 * a74 + a16 * a21 * a34 * a57 * a65 * a74 + a16 * a23 * a34 * a57 * a65 * a74 + a16 * a24 * a32 * a57 * a65 * a74 + a16 * a24 * a34 * a57 * a65 * a74
w5 = a12 * a23 * a34 * a47 * a61 * a75 + a12 * a23 * a34 * a47 * a65 * a75 + a12 * a24 * a32 * a47 * a61 * a75 + a12 * a24 * a32 * a47 * a65 * a75 + a12 * a24 * a34 * a47 * a61 * a75 + a12 * a24 * a34 * a47 * a65 * a75 + a16 * a21 * a32 * a42 * a65 * a74 + a16 * a21 * a32 * a42 * a65 * a75 + a16 * a21 * a32 * a43 * a65 * a74 + a16 * a21 * a32 * a43 * a65 * a75 + a16 * a21 * a32 * a47 * a65 * a75 + a16 * a21 * a34 * a42 * a65 * a74 + a16 * a21 * a34 * a42 * a65 * a75 + a16 * a21 * a34 * a47 * a65 * a75 + a16 * a23 * a34 * a47 * a65 * a75 + a16 * a24 * a32 * a47 * a65 * a75 + a16 * a24 * a34 * a47 * a65 * a75
w6 = a12 * a23 * a34 * a47 * a56 * a75 + a12 * a24 * a32 * a47 * a56 * a75 + a12 * a24 * a34 * a47 * a56 * a75 + a16 * a21 * a32 * a42 * a56 * a74 + a16 * a21 * a32 * a42 * a56 * a75 + a16 * a21 * a32 * a42 * a57 * a74 + a16 * a21 * a32 * a43 * a56 * a74 + a16 * a21 * a32 * a43 * a56 * a75 + a16 * a21 * a32 * a43 * a57 * a74 + a16 * a21 * a32 * a47 * a56 * a75 + a16 * a21 * a34 * a42 * a56 * a74 + a16 * a21 * a34 * a42 * a56 * a75 + a16 * a21 * a34 * a42 * a57 * a74 + a16 * a21 * a34 * a47 * a56 * a75 + a16 * a23 * a34 * a47 * a56 * a75 + a16 * a24 * a32 * a47 * a56 * a75 + a16 * a24 * a34 * a47 * a56 * a75
w7 = a12 * a23 * a34 * a47 * a56 * a61 + a12 * a23 * a34 * a47 * a57 * a61 + a12 * a23 * a34 * a47 * a57 * a65 + a12 * a24 * a32 * a47 * a56 * a61 + a12 * a24 * a32 * a47 * a57 * a61 + a12 * a24 * a32 * a47 * a57 * a65 + a12 * a24 * a34 * a47 * a56 * a61 + a12 * a24 * a34 * a47 * a57 * a61 + a12 * a24 * a34 * a47 * a57 * a65 + a16 * a21 * a32 * a42 * a57 * a65 + a16 * a21 * a32 * a43 * a57 * a65 + a16 * a21 * a32 * a47 * a57 * a65 + a16 * a21 * a34 * a42 * a57 * a65 + a16 * a21 * a34 * a47 * a57 * a65 + a16 * a23 * a34 * a47 * a57 * a65 + a16 * a24 * a32 * a47 * a57 * a65 + a16 * a24 * a34 * a47 * a57 * a65
den = wC1_1 + wC1_2 + wC1_3 + wC1_4 + wC1_5 + wC1_6 + wC1_7
v47 = a47 * C1_4 - a74 * C1_7
v42 = a42 * C1_4 - a24 * C1_2
v23 = a23 * C1_2 - a32 * C1_3
v61 = a61 * C1_1 - a16 * C1_6
eqs = [
wC1_1 ~ w1,
wC1_2 ~ w2,
wC1_3 ~ w3,
wC1_4 ~ w4,
wC1_5 ~ w5,
wC1_6 ~ w6,
wC1_7 ~ w7,
C1_1 ~ wC1_1 / den * ET_C1,
C1_2 ~ wC1_2 / den * ET_C1,
C1_3 ~ wC1_3 / den * ET_C1,
C1_4 ~ wC1_4 / den * ET_C1,
C1_7 ~ wC1_5 / den * ET_C1,
C1_5 ~ wC1_6 / den * ET_C1,
C1_6 ~ wC1_7 / den * ET_C1,
vQC1 ~ -0.5 * v47,
vROSC1 ~ v42,
vNADHC1 ~ -0.5 * v23,
vHresC1 ~ 2 * v61,
TNC1 ~ -vNADHC1 / ET_C1,
]
return System(eqs, t; name)
end
c1_gauthier (generic function with 1 method)
Markevich 2015#
Markevich 2015 mass action law model.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4426091/
The redox potential of N2 is adjusted to -150mV in B. taurus mitochondria instead of -80mV in E. coli(?).
function c1_markevich_full(; name=:c1markevich_full,
Q_n=1.8mM, QH2_n=0.2mM,
nad=500μM, nadh=500μM,
dpsi=150mV, O2=6μM, sox_m=0.01μM,
h_i=exp10(-7) * Molar, h_m=exp10(-7.6) * Molar,
DOX=0μM, ROTENONE_BLOCK=0)
@independent_variables t
D = Differential(t)
@parameters begin
Em_O2_SOX = -160mV ## O2/Superoxide redox potential
Em_FMN_FMNsq = -387mV ## FMN/FMNH- avg redox potential
Em_FMNsq_FMNH = -293mV ## FMN semiquinone/FMNH- redox potential
Em_FMN_FMNH = -340mV ## FMN/FMNH- avg redox potential
Em_NAD = -320mV ## NAD/NADH avg redox potential
Em_N3 = -250mV
Em_N2 = -150mV
Em_N1a = -370mV
Em_Q_SQ_C1 = -300mV ## -213mV in Markevich, 2015
Em_SQ_QH2_C1 = +500mV ## ~800mV (?) in Markevich, 2015
ET_C1 = 17μM ## Activity of complex I
# DOX IC50 on complex I
KI_DOX_C1 = 400μM
kf1_C1 = 83Hz / μM
KEQ1_C1 = 0.01 / μM
kr1_C1 = kf1_C1 / KEQ1_C1
kf3_C1 = 1e6Hz
KEQ3_C1 = 25μM
kr3_C1 = kf3_C1 / KEQ3_C1
kf2_C1 = 1.44e12Hz
KEQ2_C1 = exp(2iVT * (Em_FMN_FMNH - Em_NAD)) / KEQ1_C1 / KEQ3_C1
kr2_C1 = kf2_C1 / KEQ2_C1
kf4_C1 = 1Hz / μM
KEQ4_C1 = 0.001 / μM
kr4_C1 = kf4_C1 / KEQ4_C1
kf5_C1 = 2Hz / μM
KEQ5_C1 = 0.02 / μM
kr5_C1 = kf5_C1 / KEQ5_C1
kf6_C1 = 5e8Hz / μM
KEQ6_C1 = exp(iVT * (Em_N3 - Em_FMNsq_FMNH))
kr6_C1 = kf6_C1 / KEQ6_C1
kf7_C1 = 10000Hz / μM
KEQ7_C1 = exp(iVT * (Em_N2 - Em_N3))
kr7_C1 = kf7_C1 / KEQ7_C1
kf8_C1 = 10Hz / μM
KEQ8_C1 = 0.1 / μM ## Association constant for Q
kr8_C1 = kf8_C1 / KEQ8_C1
kf9_C1 = 4e5Hz / μM
KEQ9_C1 = exp(iVT * (Em_Q_SQ_C1 - Em_N2))
kr9_C1 = kf9_C1 / KEQ9_C1
kf10_C1 = 2e6Hz / μM
KEQ10_C1 = exp(iVT * (Em_N1a - Em_FMN_FMNsq))
KEQ10B_C1 = exp(iVT * (Em_FMNsq_FMNH - Em_N1a))
kr10_C1 = kf10_C1 / KEQ10_C1
kr10b_C1 = kf10_C1 / KEQ10B_C1
kf11_C1 = 1e9Hz / μM
KEQ11_C1 = exp(iVT * (Em_N3 - Em_FMN_FMNsq))
kr11_C1 = kf11_C1 / KEQ11_C1
kf13_C1 = 2.7e6Hz / μM
kf14_C1 = 1000Hz
KEQ14_C1 = 20μM ## Dissociation constant for QH2
kr14_C1 = kf14_C1 / KEQ14_C1
kf16_C1 = 2Hz / μM ## SOX production rate from If site
KEQ16_C1 = exp(iVT * (Em_O2_SOX - Em_FMNsq_FMNH))
kr16_C1 = kf16_C1 / KEQ16_C1
kf17_C1 = 0.04Hz / μM ## SOX production rate from Iq site
KEQ17_C1 = exp(iVT * (Em_O2_SOX - Em_Q_SQ_C1))
kr17_C1 = kf17_C1 / KEQ17_C1
end
@variables begin
Iq_C1(t) ## Conserved
Q_C1(t) = 0
SQ_C1(t) = 0
QH2_C1(t) = 0
FMN(t) ## Conserved
FMN_NADH(t) = 0
FMNH_NAD(t) = 0
FMN_NAD(t) = 0
FMNH_NADH(t) = 0
FMNH(t) = 0
FMNsq(t) = 0
N2_C1(t)
N2r_C1(t) = 0
N3_C1(t)
N3r_C1(t) = 0
N1a_C1(t)
N1ar_C1(t) = 0
KEQ13_C1(t)
vQC1(t)
vQH2C1(t)
vNADHC1(t)
vNADC1(t)
vROSIf(t)
vROSIq(t)
vROSC1(t)
TNC1(t) ## NADH turnover number
vHresC1(t)
end
fhm = h_m / 1E-7Molar
C1_INHIB = (1 - ROTENONE_BLOCK)
# NADH + FMN = FMN.NADH
v1 = kf1_C1 * nadh * FMN - kr1_C1 * FMN_NADH
# FMN.NADH = FMNH−.NAD+
v2 = kf2_C1 * FMN_NADH - kr2_C1 * FMNH_NAD
# FMNH−.NAD+ = FMNH− + NAD+
v3 = kf3_C1 * FMNH_NAD - kr3_C1 * FMNH * nad
# FMN + NAD+ = FMN.NAD+
v4 = kf4_C1 * nad * FMN - kr4_C1 * FMN_NAD
# FMNH− + NADH = FMNH−.NADH
v5 = kf5_C1 * FMNH * nadh - kr5_C1 * FMNH_NADH
# FMNH− + N3 = FMNHsq + N3−
v6 = kf6_C1 * FMNH * N3_C1 - kr6_C1 * FMNsq * N3r_C1
# N3− + N2 = N3 + N2−
v7 = kf7_C1 * N3r_C1 * N2_C1 - kr7_C1 * N3_C1 * N2r_C1
# Q association
q = Q_n * C1_INHIB
v8 = kf8_C1 * Iq_C1 * q - kr8_C1 * Q_C1
# CI.Q + N2− = CIQsq + N2
v9 = kf9_C1 * Q_C1 * N2r_C1 - kr9_C1 * SQ_C1 * N2_C1
# FMNHsq + N1a = FMN + N1a− + Hi+
v10 = kf10_C1 * FMNsq * N1a_C1 - kr10_C1 * FMN * N1ar_C1 * fhm
# FMNsq + N1a− = FMNH- + N1a
v10b = kf10_C1 * FMNsq * N1ar_C1 - kr10b_C1 * FMNH * N1a_C1
# FMNHsq + N3 = FMN + N3− + Hi+
v11 = kf11_C1 * FMNsq * N3_C1 - kr11_C1 * FMN * N3r_C1 * fhm
# N2 + N3− = N2− + N3
v12 = v7
# Second electron transfer
v13 = kf13_C1 * (SQ_C1 * N2r_C1 * fhm^2 - QH2_C1 * N2_C1 / KEQ13_C1)
# QH2 dissociation
qh2 = QH2_n * C1_INHIB
v14 = kf14_C1 * QH2_C1 - kr14_C1 * Iq_C1 * qh2
# Flavin site ROS generation
v16 = kf16_C1 * FMNH * O2 - kr16_C1 * FMNsq * sox_m
# Quinone site ROS generation
v17 = kf17_C1 * SQ_C1 * O2 - kr17_C1 * Q_C1 * sox_m
eqs = [
ET_C1 ~ N2r_C1 + N2_C1,
ET_C1 ~ N3r_C1 + N3_C1,
ET_C1 ~ N1ar_C1 + N1a_C1,
ET_C1 ~ Iq_C1 + Q_C1 + SQ_C1 + QH2_C1,
ET_C1 ~ FMN + FMN_NADH + FMNH_NAD + FMN_NAD + FMNH_NADH + FMNH + FMNsq,
KEQ13_C1 ~ exp(iVT * (Em_SQ_QH2_C1 - Em_N2 - 4dpsi)) * (h_m / h_i)^4,
D(FMN_NADH) ~ v1 - v2,
D(FMNH_NAD) ~ v2 - v3,
D(FMN_NAD) ~ v4,
D(FMNH_NADH) ~ v5,
D(FMNH) ~ v3 - v5 - v16 - v6 + v10b,
D(FMNsq) ~ v6 + v16 - v10 - v11 - v10b,
D(N1ar_C1) ~ v10 - v10b,
D(N3r_C1) ~ v6 + v11 - v7 - v12,
D(N2r_C1) ~ v7 + v12 - v9 - v13,
D(Q_C1) ~ v8 - v9 + v17,
D(SQ_C1) ~ v9 - v17 - v13,
D(QH2_C1) ~ v13 - v14,
# Positive: production; negative: consumption
vNADHC1 ~ -(v1 + v5),
vNADC1 ~ v3 - v4,
vQC1 ~ -v8,
vQH2C1 ~ v14,
vROSIf ~ v16,
vROSIq ~ v17,
vHresC1 ~ 4 * v13,
vROSC1 ~ vROSIf + vROSIq,
TNC1 ~ -vNADHC1 / ET_C1,
]
return System(eqs, t; name)
end
c1_markevich_full (generic function with 1 method)
Simplified Markevich#
Simplified Markevich complex I model
Rapid equilibrium at the flavin site
QSSA for the catalytic cycle at the quinone site
function c1_markevich_s(; name=:c1s,
Q_n=1800μM, QH2_n=200μM,
nad=2500μM, nadh=500μM,
dpsi=150mV, O2=6μM, sox_m=0.01μM,
h_i=exp10(-7) * Molar, h_m=exp10(-7.6) * Molar,
DOX=0μM, ROTENONE_BLOCK=0, MT_PROT=1)
@independent_variables t
D = Differential(t)
@parameters begin
ET_C1 = 17μM ## Activity of complex I
KI_DOX_C1 = 400μM ## DOX IC50 on complex I
Em_O2_SOX = -160mV ## O2/Superoxide redox potential
Em_FMN_FMNsq = -387mV ## FMN/FMNH- avg redox potential
Em_FMNsq_FMNH = -293mV ## FMN semiquinone/FMNH- redox potential
Em_FMN_FMNH = -340mV ## FMN/FMNH- avg redox potential
Em_NAD = -320mV ## NAD/NADH avg redox potential
Em_N3 = -250mV
Em_N2 = -150mV
Em_Q_SQ_C1 = -300mV ## -213mV in Markevich, 2015
Em_SQ_QH2_C1 = +500mV ## ~800mV (?) in Markevich, 2015
KI_NADH_C1 = 50μM
KD_NADH_C1 = 100μM
KI_NAD_C1 = 1000μM
KD_NAD_C1 = 25μM
# NADH + FMN = NAD+ + FMNH-
KEQ_NADH_FMN = exp(2iVT * (Em_FMN_FMNH - Em_NAD))
# 2FMNsq = (N1a) = FMN + FMNH- + H+
rKEQ_FMNsq_Dis = exp(-iVT * (Em_FMNsq_FMNH - Em_FMN_FMNsq))
# FMNH- + N3 = FMNsq + N3-
KEQ_FMNH_N3 = exp(iVT * (Em_N3 - Em_FMNsq_FMNH))
# N3- + N2 = N3 + N2-
kf7_C1 = 10000Hz / μM
rKEQ7_C1 = exp(-iVT * (Em_N2 - Em_N3))
kb7_C1 = kf7_C1 * rKEQ7_C1
kf8_C1 = 10Hz / μM
rKEQ8_C1 = 10μM
kb8_C1 = kf8_C1 * rKEQ8_C1
kf9_C1 = 4E5Hz / μM
rKEQ9_C1 = exp(-iVT * (Em_Q_SQ_C1 - Em_N2))
kb9_C1 = kf9_C1 * rKEQ9_C1
kf13_C1 = 2.7e6Hz / μM
kf14_C1 = 1000Hz
rKEQ14_C1 = inv(20μM)
kb14_C1 = kf14_C1 * rKEQ14_C1
kf16_C1 = 2Hz / μM ## SOX production rate from If site
rKEQ16_C1 = exp(-iVT * (Em_O2_SOX - Em_FMNsq_FMNH))
kb16_C1 = kf16_C1 * rKEQ16_C1
kf17_C1 = 0.04Hz / μM ## SOX production rate from Iq site
rKEQ17_C1 = exp(-iVT * (Em_O2_SOX - Em_Q_SQ_C1))
kb17_C1 = kf17_C1 * rKEQ17_C1
end
@variables begin
# Flavin site
FMN(t)
FMN_NAD(t)
FMNsq(t)
FMNH(t)
FMNH_NADH(t)
FMN_NADH(t)
FMNH_NAD(t)
# FeS cluster
N3_C1(t)
N3r_C1(t)
N2_C1(t)
N2r_C1(t) = 0
# Quinone site
C1(t)
Q_C1(t)
SQ_C1(t)
QH2_C1(t)
rKEQ_N2r_SQ(t)
# Reaction rates
vQC1(t)
vQH2C1(t)
vROSC1(t)
vROSIf(t)
vROSIq(t)
vNADHC1(t)
vNADC1(t)
TNC1(t)
vHresC1(t)
end
C1_CONC = ET_C1 * MT_PROT
C1_INHIB = (1 - ROTENONE_BLOCK) / (1 + (DOX / KI_DOX_C1)^3)
# Mitochondrial pH factor
fhm = h_m * inv(1E-7Molar)
# Flavin site in rapid equilibrium
# Weights in the flavin site
wFMN = 1
wFMN_NAD = wFMN * nad / KI_NAD_C1
wFMN_NADH = wFMN * nadh / KD_NADH_C1
wFMNH = wFMN * (nadh / nad) * KEQ_NADH_FMN
wFMNH_NAD = wFMNH * nad / KD_NAD_C1
wFMNH_NADH = wFMNH * nadh / KI_NADH_C1
wFMNsq = NaNMath.sqrt(wFMN * wFMNH * rKEQ_FMNsq_Dis * fhm)
fDen = wFMN + wFMN_NAD + wFMNH + wFMNH_NADH + wFMNsq + wFMN_NADH + wFMNH_NAD
fC1 = C1_CONC / fDen
# Flavin site ROS generation
v16 = kf16_C1 * FMNH * O2 - kb16_C1 * FMNsq * sox_m
# N3− + N2 = N3 + N2−
v7 = kf7_C1 * N3r_C1 * N2_C1 - kb7_C1 * N3_C1 * N2r_C1
v12 = v7
# Quinone site state transition rates
# C1 + Q = Q_C1
b12 = kf8_C1 * Q_n * C1_INHIB
b21 = kb8_C1
v8 = b12 * C1 - b21 * Q_C1
# Q_C1 + N2r = SQ_C1 + N2
b23a = kf9_C1 * N2r_C1
b32a = kb9_C1 * N2_C1
v9 = b23a * Q_C1 - b32a * SQ_C1
# C1_SQ + N2r + 6Hm = C1_QH2 + N2 + 4Hi
b34 = kf13_C1 * N2r_C1 * fhm^2
b43 = kf13_C1 * rKEQ_N2r_SQ * N2_C1
v13 = b34 * SQ_C1 - b43 * QH2_C1
# C1_QH2 = C1 + QH2
b41 = kf14_C1
b14 = kb14_C1 * QH2_n * C1_INHIB
v14 = b41 * QH2_C1 - b14 * C1
# C1_SQ + O2 = C1_Q + sox
b32b = kf17_C1 * O2
b23b = kb17_C1 * sox_m
v17 = b32b * SQ_C1 - b23b * Q_C1
b23 = b23a + b23b
b32 = b32a + b32b
# KA pattern
wC1 = b21 * b32 * b41 + b21 * b32 * b43 + b21 * b34 * b41 + b23 * b34 * b41
wC1_Q = b12 * b32 * b41 + b12 * b32 * b43 + b12 * b34 * b41 + b14 * b32 * b43
wC1_SQ = b12 * b23 * b41 + b12 * b23 * b43 + b14 * b21 * b43 + b14 * b23 * b43
wC1_QH2 = b12 * b23 * b34 + b14 * b21 * b32 + b14 * b21 * b34 + b14 * b23 * b34
qDen = wC1 + wC1_Q + wC1_SQ + wC1_QH2
qC1 = C1_CONC / qDen
eqs = [
rKEQ_N2r_SQ ~ exp(-iVT * (Em_SQ_QH2_C1 - Em_N2 - 4dpsi)) * (h_i / h_m)^4,
FMN ~ wFMN * fC1,
FMN_NAD ~ wFMN_NAD * fC1,
FMNH ~ wFMNH * fC1,
FMNsq ~ wFMNsq * fC1,
FMNH_NADH ~ wFMNH_NADH * fC1,
FMN_NADH ~ wFMN_NADH * fC1,
FMNH_NAD ~ wFMNH_NAD * fC1,
N3_C1 ~ C1_CONC * FMNsq / (FMNsq + FMNH * KEQ_FMNH_N3),
C1_CONC ~ N3_C1 + N3r_C1,
C1_CONC ~ N2_C1 + N2r_C1,
D(N2r_C1) ~ v7 + v12 - v9 - v13,
C1 ~ wC1 * qC1,
Q_C1 ~ wC1_Q * qC1,
SQ_C1 ~ wC1_SQ * qC1,
QH2_C1 ~ wC1_QH2 * qC1,
vQC1 ~ -v8,
vNADHC1 ~ -0.5 * (v7 + v12 + v16),
vROSIf ~ v16,
vROSIq ~ v17,
vROSC1 ~ vROSIf + vROSIq,
vQH2C1 ~ v14,
vHresC1 ~ 4 * v13,
vNADC1 ~ -vNADHC1,
TNC1 ~ vNADC1 / C1_CONC,
]
return System(eqs, t; name)
end
c1_markevich_s (generic function with 1 method)
Quinone site#
Quinone site complex I model, assuming N2 at equilibrium with the flavin site. Adapted from the simplified Markevich complex I model.
function c1_q(; name=:c1q,
Q_n=1800μM, QH2_n=200μM,
nad=2500μM, nadh=500μM,
dpsi=150mV, O2=6μM, sox_m=0.01μM,
h_i=exp10(-7) * Molar, h_m=exp10(-7.6) * Molar,
DOX=0μM, ROTENONE_BLOCK=0, MT_PROT=1)
@independent_variables t
D = Differential(t)
@parameters begin
ET_C1 = 17μM ## Activity of complex I
KI_DOX_C1 = 400μM ## DOX IC50 on complex I
Em_O2_SOX = -160mV ## O2/Superoxide redox potential
Em_FMN_FMNsq = -387mV ## FMN/FMNH- avg redox potential
Em_FMNsq_FMNH = -293mV ## FMN semiquinone/FMNH- redox potential
Em_FMN_FMNH = -340mV ## FMN/FMNH- avg redox potential
Em_NAD = -320mV ## NAD/NADH avg redox potential
Em_N3 = -250mV
Em_N2 = -150mV
Em_Q_SQ_C1 = -300mV ## -213mV in Markevich's model
Em_SQ_QH2_C1 = +500mV
KI_NADH_C1 = 50μM
KD_NADH_C1 = 100μM
KI_NAD_C1 = 1000μM
KD_NAD_C1 = 25μM
# NADH + FMN = NAD+ + FMNH-
KEQ_NADH_FMN = exp(2iVT * (Em_FMN_FMNH - Em_NAD))
# 2FMNsq = (ISC) = FMN + FMNH- + H+
rKEQ_FMNsq_Dis = exp(-iVT * (Em_FMNsq_FMNH - Em_FMN_FMNsq))
# FMNH- + N2 = FMNsq + N2-
KEQ_FMNH_N2 = exp(iVT * (Em_N2 - Em_FMNsq_FMNH))
# I + Q = IQ
kf8_C1 = 10Hz / μM
KEQ8_C1 = 0.1 / μM
kr8_C1 = kf8_C1 / KEQ8_C1
# Q + e- = Q-
kf9_C1 = 1e4Hz / μM ## 4e5Hz / μM
KEQ9_C1 = exp(iVT * (Em_Q_SQ_C1 - Em_N2))
kr9_C1 = kf9_C1 / KEQ9_C1
# Q- + e- + 6Hm = QH2 + 4Hi
kf13_C1 = 6e4Hz / μM ## 2.7e6Hz / μM
# C1_QH2 = C1 + QH2
kf14_C1 = 1000Hz
KEQ14_C1 = 20μM
kr14_C1 = kf14_C1 / KEQ14_C1 ## 50Hz / μM
kf16_C1 = 2Hz / μM ## SOX production rate from If site
KEQ16_C1 = exp(iVT * (Em_O2_SOX - Em_FMNsq_FMNH))
kr16_C1 = kf16_C1 / KEQ16_C1
kf17_C1 = 0.04Hz / μM ## SOX production rate from Iq site
KEQ17_C1 = exp(iVT * (Em_O2_SOX - Em_Q_SQ_C1))
kr17_C1 = kf17_C1 / KEQ17_C1
end
@variables begin
# Flavin site
FMN(t)
FMN_NAD(t)
FMNsq(t)
FMNH(t)
FMNH_NADH(t)
FMN_NADH(t)
FMNH_NAD(t)
N2_C1(t)
N2r_C1(t)
# Quinone site
I_C1(t) ## Conserved
Q_C1(t) = 0
SQ_C1(t) = 0
QH2_C1(t) = 0
rKEQ_N2r_SQ(t)
# Reaction rates
vQC1(t)
vQH2C1(t)
vROSC1(t)
vROSIf(t)
vROSIq(t)
vNADHC1(t)
vNADC1(t)
TNC1(t)
vHresC1(t)
end
C1_CONC = ET_C1 * MT_PROT
C1_INHIB = (1 - ROTENONE_BLOCK) / (1 + (DOX / KI_DOX_C1)^3)
fhm = h_m * inv(1E-7Molar) ## Mitochondrial pH factor
# Flavin site in rapid equilibrium
# Weights in the flavin site
wFMN = 1
wFMN_NAD = wFMN * nad / KI_NAD_C1
wFMN_NADH = wFMN * nadh / KD_NADH_C1
wFMNH = wFMN * (nadh / nad) * KEQ_NADH_FMN
wFMNH_NAD = wFMNH * nad / KD_NAD_C1
wFMNH_NADH = wFMNH * nadh / KI_NADH_C1
wFMNsq = NaNMath.sqrt(wFMN * wFMNH * rKEQ_FMNsq_Dis * fhm)
fDen = wFMN + wFMN_NAD + wFMNH + wFMNH_NADH + wFMNsq + wFMN_NADH + wFMNH_NAD
fC1 = C1_CONC / fDen
# Quinone site state transitions
# Q + C1 = Q_C1
q = Q_n * C1_INHIB
v8 = kf8_C1 * I_C1 * q - kr8_C1 * Q_C1
# Q_C1 + N2r = SQ_C1 + N2
v9 = kf9_C1 * Q_C1 * N2r_C1 - kr9_C1 * SQ_C1 * N2_C1
# SQ_C1 + N2r + 6Hm = QH2_C1 + N2 + 4Hi
v13 = kf13_C1 * (fhm^2 * N2r_C1 * SQ_C1 - rKEQ_N2r_SQ * N2_C1 * QH2_C1)
# QH2_C1 = QH2 + C1
qh2 = QH2_n * C1_INHIB
v14 = kf14_C1 * QH2_C1 - kr14_C1 * I_C1 * qh2
# Flavin site ROS production
v16 = kf16_C1 * FMNH * O2 - kr16_C1 * FMNsq * sox_m
# Quinone site ROS production
v17 = kf17_C1 * SQ_C1 * O2 - kr17_C1 * Q_C1 * sox_m
eqs = [
rKEQ_N2r_SQ ~ exp(-iVT * (Em_SQ_QH2_C1 - Em_N2 - 4dpsi)) * (h_i / h_m)^4,
FMN ~ wFMN * fC1,
FMN_NAD ~ wFMN_NAD * fC1,
FMNH ~ wFMNH * fC1,
FMNsq ~ wFMNsq * fC1,
FMNH_NADH ~ wFMNH_NADH * fC1,
FMN_NADH ~ wFMN_NADH * fC1,
FMNH_NAD ~ wFMNH_NAD * fC1,
N2_C1 ~ C1_CONC * FMNsq / (FMNsq + FMNH * KEQ_FMNH_N2),
C1_CONC ~ N2r_C1 + N2_C1,
C1_CONC ~ I_C1 + Q_C1 + SQ_C1 + QH2_C1,
D(Q_C1) ~ v8 - v9 + v17,
D(SQ_C1) ~ v9 - v13 - v17,
D(QH2_C1) ~ v13 - v14,
vNADHC1 ~ -0.5 * (v9 + v13 + v16),
vROSIf ~ v16,
vROSIq ~ v17,
vROSC1 ~ vROSIf + vROSIq,
vQH2C1 ~ v14,
vQC1 ~ -v8,
vHresC1 ~ 4 * v13,
vNADC1 ~ -vNADHC1,
TNC1 ~ vNADC1 / C1_CONC,
]
return System(eqs, t; name)
end
c1_q (generic function with 1 method)
Prepare problem#
alg = DynamicSS(TRBDF2())
ealg = EnsembleThreads()
SciMLBase.EnsembleThreads()
@parameters begin
Q_n = 1.8mM
QH2_n = 0.2mM
nad = 2500μM
nadh = 500μM
dpsi = 150mV
sox_m = 0.01μM
end
\[\begin{split} \begin{equation}
\left[
\begin{array}{c}
\mathtt{Q\_n} \\
\mathtt{QH2\_n} \\
\mathtt{nad} \\
\mathtt{nadh} \\
\mathtt{dpsi} \\
\mathtt{sox\_m} \\
\end{array}
\right]
\end{equation}
\end{split}\]
# Helper function
extract(sim, k) = map(s -> s[k], sim)
extract (generic function with 1 method)
sys_q = c1_q(; Q_n, QH2_n, nad, nadh, dpsi, sox_m) |> mtkcompile
prob_q = SteadyStateProblem(sys_q, [
sys_q.ET_C1 => 17μM,
sys_q.kf8_C1 => 5Hz / μM,
sys_q.kf9_C1 => 1000Hz / μM,
sys_q.kf13_C1 => 10000Hz / μM,
sys_q.kf16_C1 => 20Hz / μM,
sys_q.kf17_C1 => 0.4Hz / μM,
])
SteadyStateProblem with uType Vector{Float64}. In-place: true
u0: 3-element Vector{Float64}:
0.0
0.0
0.0
sys_m = c1_markevich_full(; Q_n, QH2_n, nad, nadh, dpsi, sox_m) |> mtkcompile
prob_m = SteadyStateProblem(sys_m, [
sys_m.ET_C1 => 17μM,
sys_m.kf16_C1 => 20Hz / μM,
sys_m.kf17_C1 => 0.4Hz / μM,
])
SteadyStateProblem with uType Vector{Float64}. In-place: true
u0: 12-element Vector{Float64}:
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
# The parameter for ROS generation rate is adjusted (x10000) to be comparable to ROS generation from complex III
sys_g = c1_gauthier(; Q_n, QH2_n, nad, nadh, dpsi, sox_m) |> mtkcompile
prob_g = SteadyStateProblem(sys_g, [
sys_g.K42_C1 => 6.0318Hz / mM * 10000
])
SteadyStateProblem with uType Nothing. In-place: true
u0: nothing
Varying MMP#
Simulations#
dpsirange = 100mV:1mV:200mV
alter_dpsi = (prob, i, repeat) -> begin
prob.ps[dpsi] = dpsirange[i]
prob
end
#7 (generic function with 1 method)
@time mmp_q = solve(EnsembleProblem(prob_q; prob_func=alter_dpsi), alg, ealg; trajectories=length(dpsirange), abstol=1e-8, reltol=1e-8)
7.990839 seconds (25.29 M allocations: 1.244 GiB, 3.08% gc time, 139.67% compilation time: <1% of which was recompilation)
EnsembleSolution Solution of length 101 with uType:
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Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xe45f9644, 0xd2b45374, 0xeb266526, 0x51d5e17c, 0x03b62279), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xd9efa69c, 0xc30d7ef0, 0x1f35a64f, 0x8a780b3b, 0x62be22b7), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xe45f9644, 0xd2b45374, 0xeb266526, 0x51d5e17c, 0x03b62279), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xd9efa69c, 0xc30d7ef0, 0x1f35a64f, 0x8a780b3b, 0x62be22b7), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardODEProblem}, OrdinaryDiffEqSDIRK.TRBDF2{0, ADTypes.AutoForwardDiff{nothing, ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}}, Nothing, OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, typeof(OrdinaryDiffEqCore.DEFAULT_PRECS), Val{:forward}(), true, nothing, typeof(OrdinaryDiffEqCore.trivial_limiter!)}, OrdinaryDiffEqCore.InterpolationData{SciMLBase.ODEFunction{true, true, SciMLBase.ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xc7e7a5fb, 0x0547168e, 0x5240d75e, 0xf96dfe59, 0x32e41e5a), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xeba74dd5, 0xd4c855f8, 0x618377dc, 0x6abe5830, 0x269334b1), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xe45f9644, 0xd2b45374, 0xeb266526, 0x51d5e17c, 0x03b62279), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xd9efa69c, 0xc30d7ef0, 0x1f35a64f, 0x8a780b3b, 0x62be22b7), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xe45f9644, 0xd2b45374, 0xeb266526, 0x51d5e17c, 0x03b62279), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xd9efa69c, 0xc30d7ef0, 0x1f35a64f, 0x8a780b3b, 0x62be22b7), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Vector{Vector{Float64}}, Vector{Float64}, Vector{Vector{Vector{Float64}}}, Nothing, cacheType, Nothing}, SciMLBase.DEStats, Nothing, Nothing, Nothing, Nothing}, Nothing, Nothing, Nothing} where cacheType<:(OrdinaryDiffEqSDIRK.TRBDF2Cache{Vector{Float64}, Vector{Float64}, Vector{Float64}, OrdinaryDiffEqSDIRK.TRBDF2Tableau{Float64, Float64}, N, typeof(OrdinaryDiffEqCore.trivial_limiter!)} where N<:(OrdinaryDiffEqNonlinearSolve.NLSolver{OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, true, Vector{Float64}, Float64, Nothing, Float64, OrdinaryDiffEqNonlinearSolve.NLNewtonCache{Vector{Float64}, Float64, Float64, Vector{Float64}, Matrix{Float64}, Matrix{Float64}, SciMLBase.UJacobianWrapper{true, SciMLBase.ODEFunction{true, true, SciMLBase.ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xc7e7a5fb, 0x0547168e, 0x5240d75e, 0xf96dfe59, 0x32e41e5a), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xeba74dd5, 0xd4c855f8, 0x618377dc, 0x6abe5830, 0x269334b1), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xe45f9644, 0xd2b45374, 0xeb266526, 0x51d5e17c, 0x03b62279), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xd9efa69c, 0xc30d7ef0, 0x1f35a64f, 0x8a780b3b, 0x62be22b7), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xe45f9644, 0xd2b45374, 0xeb266526, 0x51d5e17c, 0x03b62279), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xd9efa69c, 0xc30d7ef0, 0x1f35a64f, 0x8a780b3b, 0x62be22b7), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Float64, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}}, jcType, LinearSolve.LinearCache{Matrix{Float64}, Vector{Float64}, Vector{Float64}, SciMLBase.NullParameters, LinearSolve.DefaultLinearSolver, LinearSolve.DefaultLinearSolverInit{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, LinearAlgebra.QRCompactWY{Float64, Matrix{Float64}, Matrix{Float64}}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Vector{Int64}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Vector{Int64}}, Nothing, Nothing, Nothing, LinearAlgebra.SVD{Float64, Float64, Matrix{Float64}, Vector{Float64}}, LinearAlgebra.Cholesky{Float64, Matrix{Float64}}, LinearAlgebra.Cholesky{Float64, Matrix{Float64}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int32}}, Base.RefValue{Int32}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Base.RefValue{Int64}}, LinearAlgebra.QRPivoted{Float64, Matrix{Float64}, Vector{Float64}, Vector{Int64}}, Nothing, Nothing, Nothing, Nothing, Nothing}, LinearSolve.InvPreconditioner{LinearAlgebra.Diagonal{Float64, Vector{Float64}}}, LinearAlgebra.Diagonal{Float64, Vector{Float64}}, Float64, Bool, LinearSolve.LinearSolveAdjoint{Missing}}}, Float64} where jcType<:Tuple{DifferentiationInterfaceForwardDiffExt.ForwardDiffTwoArgJacobianPrep{Nothing, C, Tuple{}} where C<:(ForwardDiff.JacobianConfig{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A, <:Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A, Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A}} where _A), DifferentiationInterfaceForwardDiffExt.ForwardDiffTwoArgJacobianPrep{Nothing, C, Tuple{}} where C<:(ForwardDiff.JacobianConfig{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A, <:Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A, Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A}} where _A)})), SciMLBase.NonlinearSolution{Float64, 1, Vector{Float64}, Vector{Float64}, SciMLBase.SteadyStateProblem{Vector{Float64}, true, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xc7e7a5fb, 0x0547168e, 0x5240d75e, 0xf96dfe59, 0x32e41e5a), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xeba74dd5, 0xd4c855f8, 0x618377dc, 0x6abe5830, 0x269334b1), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xe45f9644, 0xd2b45374, 0xeb266526, 0x51d5e17c, 0x03b62279), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xd9efa69c, 0xc30d7ef0, 0x1f35a64f, 0x8a780b3b, 0x62be22b7), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}}, SteadyStateDiffEq.DynamicSS{OrdinaryDiffEqSDIRK.TRBDF2{0, ADTypes.AutoForwardDiff{nothing, ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}}, Nothing, OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, typeof(OrdinaryDiffEqCore.DEFAULT_PRECS), Val{:forward}(), true, nothing, typeof(OrdinaryDiffEqCore.trivial_limiter!)}, Float64}, SciMLBase.ODESolution{Float64, 2, Vector{Vector{Float64}}, Nothing, Nothing, Vector{Float64}, Vector{Vector{Vector{Float64}}}, Nothing, SciMLBase.ODEProblem{Vector{Float64}, Tuple{Float64, Float64}, true, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.ODEFunction{true, true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xc7e7a5fb, 0x0547168e, 0x5240d75e, 0xf96dfe59, 0x32e41e5a), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xeba74dd5, 0xd4c855f8, 0x618377dc, 0x6abe5830, 0x269334b1), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xe45f9644, 0xd2b45374, 0xeb266526, 0x51d5e17c, 0x03b62279), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xd9efa69c, 0xc30d7ef0, 0x1f35a64f, 0x8a780b3b, 0x62be22b7), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardODEProblem}, OrdinaryDiffEqSDIRK.TRBDF2{0, ADTypes.AutoForwardDiff{nothing, ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}}, Nothing, OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, typeof(OrdinaryDiffEqCore.DEFAULT_PRECS), Val{:forward}(), true, nothing, typeof(OrdinaryDiffEqCore.trivial_limiter!)}, OrdinaryDiffEqCore.InterpolationData{SciMLBase.ODEFunction{true, true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xc7e7a5fb, 0x0547168e, 0x5240d75e, 0xf96dfe59, 0x32e41e5a), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xeba74dd5, 0xd4c855f8, 0x618377dc, 0x6abe5830, 0x269334b1), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xe45f9644, 0xd2b45374, 0xeb266526, 0x51d5e17c, 0x03b62279), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xd9efa69c, 0xc30d7ef0, 0x1f35a64f, 0x8a780b3b, 0x62be22b7), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Vector{Vector{Float64}}, Vector{Float64}, Vector{Vector{Vector{Float64}}}, Nothing, cacheType, Nothing}, SciMLBase.DEStats, Nothing, Nothing, Nothing, Nothing}, Nothing, Nothing, Nothing} where cacheType<:(OrdinaryDiffEqSDIRK.TRBDF2Cache{Vector{Float64}, Vector{Float64}, Vector{Float64}, OrdinaryDiffEqSDIRK.TRBDF2Tableau{Float64, Float64}, N, typeof(OrdinaryDiffEqCore.trivial_limiter!)} where N<:(OrdinaryDiffEqNonlinearSolve.NLSolver{OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, true, Vector{Float64}, Float64, Nothing, Float64, OrdinaryDiffEqNonlinearSolve.NLNewtonCache{Vector{Float64}, Float64, Float64, Vector{Float64}, Matrix{Float64}, Matrix{Float64}, SciMLBase.UJacobianWrapper{true, SciMLBase.ODEFunction{true, true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xc7e7a5fb, 0x0547168e, 0x5240d75e, 0xf96dfe59, 0x32e41e5a), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xeba74dd5, 0xd4c855f8, 0x618377dc, 0x6abe5830, 0x269334b1), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xe45f9644, 0xd2b45374, 0xeb266526, 0x51d5e17c, 0x03b62279), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xd9efa69c, 0xc30d7ef0, 0x1f35a64f, 0x8a780b3b, 0x62be22b7), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Float64, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}}, jcType, LinearSolve.LinearCache{Matrix{Float64}, Vector{Float64}, Vector{Float64}, SciMLBase.NullParameters, LinearSolve.DefaultLinearSolver, LinearSolve.DefaultLinearSolverInit{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, LinearAlgebra.QRCompactWY{Float64, Matrix{Float64}, Matrix{Float64}}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Vector{Int64}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Vector{Int64}}, Nothing, Nothing, Nothing, LinearAlgebra.SVD{Float64, Float64, Matrix{Float64}, Vector{Float64}}, LinearAlgebra.Cholesky{Float64, Matrix{Float64}}, LinearAlgebra.Cholesky{Float64, Matrix{Float64}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int32}}, Base.RefValue{Int32}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Base.RefValue{Int64}}, LinearAlgebra.QRPivoted{Float64, Matrix{Float64}, Vector{Float64}, Vector{Int64}}, Nothing, Nothing, Nothing, Nothing, Nothing}, LinearSolve.InvPreconditioner{LinearAlgebra.Diagonal{Float64, Vector{Float64}}}, LinearAlgebra.Diagonal{Float64, Vector{Float64}}, Float64, Bool, LinearSolve.LinearSolveAdjoint{Missing}}}, Float64} where jcType<:Tuple{DifferentiationInterfaceForwardDiffExt.ForwardDiffTwoArgJacobianPrep{Nothing, C, Tuple{}} where C<:(ForwardDiff.JacobianConfig{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A, <:Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A, Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A}} where _A), DifferentiationInterfaceForwardDiffExt.ForwardDiffTwoArgJacobianPrep{Nothing, C, Tuple{}} where C<:(ForwardDiff.JacobianConfig{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A, <:Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A, Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A}} where _A)}))}
@time mmp_m = solve(EnsembleProblem(prob_m; prob_func=alter_dpsi), alg, ealg; trajectories=length(dpsirange), abstol=1e-8, reltol=1e-8)
14.936244 seconds (34.28 M allocations: 3.860 GiB, 17.74% gc time, 55.50% compilation time)
EnsembleSolution Solution of length 101 with uType:
Union{SciMLBase.NonlinearSolution{Float64, 1, Vector{Float64}, Vector{Float64}, SciMLBase.SteadyStateProblem{Vector{Float64}, true, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x67957fcf, 0xde1396e6, 0xf3fda331, 0xb01c0719, 0xe33e37e3), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xdf32e04c, 0x39d89b79, 0x618fc0fd, 0x44e9f60d, 0x94b90109), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xcf0c5d7f, 0x6e27a42b, 0xdd85b0d6, 0x85601580, 0x710ecab7), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xa1574565, 0x91efc8e9, 0x7a603f3f, 0x9970dfa2, 0x3a16d698), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}}, SteadyStateDiffEq.DynamicSS{OrdinaryDiffEqSDIRK.TRBDF2{0, ADTypes.AutoForwardDiff{nothing, ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}}, Nothing, OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, typeof(OrdinaryDiffEqCore.DEFAULT_PRECS), Val{:forward}(), true, nothing, typeof(OrdinaryDiffEqCore.trivial_limiter!)}, Float64}, SciMLBase.ODESolution{Float64, 2, Vector{Vector{Float64}}, Nothing, Nothing, Vector{Float64}, Vector{Vector{Vector{Float64}}}, Nothing, SciMLBase.ODEProblem{Vector{Float64}, Tuple{Float64, Float64}, true, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.ODEFunction{true, true, SciMLBase.ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x67957fcf, 0xde1396e6, 0xf3fda331, 0xb01c0719, 0xe33e37e3), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xdf32e04c, 0x39d89b79, 0x618fc0fd, 0x44e9f60d, 0x94b90109), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xcf0c5d7f, 0x6e27a42b, 0xdd85b0d6, 0x85601580, 0x710ecab7), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xa1574565, 0x91efc8e9, 0x7a603f3f, 0x9970dfa2, 0x3a16d698), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xcf0c5d7f, 0x6e27a42b, 0xdd85b0d6, 0x85601580, 0x710ecab7), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xa1574565, 0x91efc8e9, 0x7a603f3f, 0x9970dfa2, 0x3a16d698), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardODEProblem}, OrdinaryDiffEqSDIRK.TRBDF2{0, ADTypes.AutoForwardDiff{nothing, ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}}, Nothing, OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, typeof(OrdinaryDiffEqCore.DEFAULT_PRECS), Val{:forward}(), true, nothing, typeof(OrdinaryDiffEqCore.trivial_limiter!)}, OrdinaryDiffEqCore.InterpolationData{SciMLBase.ODEFunction{true, true, SciMLBase.ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x67957fcf, 0xde1396e6, 0xf3fda331, 0xb01c0719, 0xe33e37e3), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xdf32e04c, 0x39d89b79, 0x618fc0fd, 0x44e9f60d, 0x94b90109), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xcf0c5d7f, 0x6e27a42b, 0xdd85b0d6, 0x85601580, 0x710ecab7), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xa1574565, 0x91efc8e9, 0x7a603f3f, 0x9970dfa2, 0x3a16d698), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xcf0c5d7f, 0x6e27a42b, 0xdd85b0d6, 0x85601580, 0x710ecab7), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xa1574565, 0x91efc8e9, 0x7a603f3f, 0x9970dfa2, 0x3a16d698), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Vector{Vector{Float64}}, Vector{Float64}, Vector{Vector{Vector{Float64}}}, Nothing, cacheType, Nothing}, SciMLBase.DEStats, Nothing, Nothing, Nothing, Nothing}, Nothing, Nothing, Nothing} where cacheType<:(OrdinaryDiffEqSDIRK.TRBDF2Cache{Vector{Float64}, Vector{Float64}, Vector{Float64}, OrdinaryDiffEqSDIRK.TRBDF2Tableau{Float64, Float64}, N, typeof(OrdinaryDiffEqCore.trivial_limiter!)} where N<:(OrdinaryDiffEqNonlinearSolve.NLSolver{OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, true, Vector{Float64}, Float64, Nothing, Float64, OrdinaryDiffEqNonlinearSolve.NLNewtonCache{Vector{Float64}, Float64, Float64, Vector{Float64}, Matrix{Float64}, Matrix{Float64}, SciMLBase.UJacobianWrapper{true, SciMLBase.ODEFunction{true, true, SciMLBase.ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x67957fcf, 0xde1396e6, 0xf3fda331, 0xb01c0719, 0xe33e37e3), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xdf32e04c, 0x39d89b79, 0x618fc0fd, 0x44e9f60d, 0x94b90109), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xcf0c5d7f, 0x6e27a42b, 0xdd85b0d6, 0x85601580, 0x710ecab7), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xa1574565, 0x91efc8e9, 0x7a603f3f, 0x9970dfa2, 0x3a16d698), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xcf0c5d7f, 0x6e27a42b, 0xdd85b0d6, 0x85601580, 0x710ecab7), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xa1574565, 0x91efc8e9, 0x7a603f3f, 0x9970dfa2, 0x3a16d698), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Float64, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}}, jcType, LinearSolve.LinearCache{Matrix{Float64}, Vector{Float64}, Vector{Float64}, SciMLBase.NullParameters, LinearSolve.DefaultLinearSolver, LinearSolve.DefaultLinearSolverInit{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, LinearAlgebra.QRCompactWY{Float64, Matrix{Float64}, Matrix{Float64}}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Vector{Int64}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Vector{Int64}}, Nothing, Nothing, Nothing, LinearAlgebra.SVD{Float64, Float64, Matrix{Float64}, Vector{Float64}}, LinearAlgebra.Cholesky{Float64, Matrix{Float64}}, LinearAlgebra.Cholesky{Float64, Matrix{Float64}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int32}}, Base.RefValue{Int32}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Base.RefValue{Int64}}, LinearAlgebra.QRPivoted{Float64, Matrix{Float64}, Vector{Float64}, Vector{Int64}}, Nothing, Nothing, Nothing, Nothing, Nothing}, LinearSolve.InvPreconditioner{LinearAlgebra.Diagonal{Float64, Vector{Float64}}}, LinearAlgebra.Diagonal{Float64, Vector{Float64}}, Float64, Bool, LinearSolve.LinearSolveAdjoint{Missing}}}, Float64} where jcType<:Tuple{DifferentiationInterfaceForwardDiffExt.ForwardDiffTwoArgJacobianPrep{Nothing, C, Tuple{}} where C<:(ForwardDiff.JacobianConfig{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A, <:Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A, Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A}} where _A), DifferentiationInterfaceForwardDiffExt.ForwardDiffTwoArgJacobianPrep{Nothing, C, Tuple{}} where C<:(ForwardDiff.JacobianConfig{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A, <:Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A, Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A}} where _A)})), SciMLBase.NonlinearSolution{Float64, 1, Vector{Float64}, Vector{Float64}, SciMLBase.SteadyStateProblem{Vector{Float64}, true, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x67957fcf, 0xde1396e6, 0xf3fda331, 0xb01c0719, 0xe33e37e3), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xdf32e04c, 0x39d89b79, 0x618fc0fd, 0x44e9f60d, 0x94b90109), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xcf0c5d7f, 0x6e27a42b, 0xdd85b0d6, 0x85601580, 0x710ecab7), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xa1574565, 0x91efc8e9, 0x7a603f3f, 0x9970dfa2, 0x3a16d698), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}}, SteadyStateDiffEq.DynamicSS{OrdinaryDiffEqSDIRK.TRBDF2{0, ADTypes.AutoForwardDiff{nothing, ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}}, Nothing, OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, typeof(OrdinaryDiffEqCore.DEFAULT_PRECS), Val{:forward}(), true, nothing, typeof(OrdinaryDiffEqCore.trivial_limiter!)}, Float64}, SciMLBase.ODESolution{Float64, 2, Vector{Vector{Float64}}, Nothing, Nothing, Vector{Float64}, Vector{Vector{Vector{Float64}}}, Nothing, SciMLBase.ODEProblem{Vector{Float64}, Tuple{Float64, Float64}, true, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.ODEFunction{true, true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x67957fcf, 0xde1396e6, 0xf3fda331, 0xb01c0719, 0xe33e37e3), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xdf32e04c, 0x39d89b79, 0x618fc0fd, 0x44e9f60d, 0x94b90109), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xcf0c5d7f, 0x6e27a42b, 0xdd85b0d6, 0x85601580, 0x710ecab7), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xa1574565, 0x91efc8e9, 0x7a603f3f, 0x9970dfa2, 0x3a16d698), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardODEProblem}, OrdinaryDiffEqSDIRK.TRBDF2{0, ADTypes.AutoForwardDiff{nothing, ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}}, Nothing, OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, typeof(OrdinaryDiffEqCore.DEFAULT_PRECS), Val{:forward}(), true, nothing, typeof(OrdinaryDiffEqCore.trivial_limiter!)}, OrdinaryDiffEqCore.InterpolationData{SciMLBase.ODEFunction{true, true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x67957fcf, 0xde1396e6, 0xf3fda331, 0xb01c0719, 0xe33e37e3), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xdf32e04c, 0x39d89b79, 0x618fc0fd, 0x44e9f60d, 0x94b90109), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xcf0c5d7f, 0x6e27a42b, 0xdd85b0d6, 0x85601580, 0x710ecab7), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xa1574565, 0x91efc8e9, 0x7a603f3f, 0x9970dfa2, 0x3a16d698), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Vector{Vector{Float64}}, Vector{Float64}, Vector{Vector{Vector{Float64}}}, Nothing, cacheType, Nothing}, SciMLBase.DEStats, Nothing, Nothing, Nothing, Nothing}, Nothing, Nothing, Nothing} where cacheType<:(OrdinaryDiffEqSDIRK.TRBDF2Cache{Vector{Float64}, Vector{Float64}, Vector{Float64}, OrdinaryDiffEqSDIRK.TRBDF2Tableau{Float64, Float64}, N, typeof(OrdinaryDiffEqCore.trivial_limiter!)} where N<:(OrdinaryDiffEqNonlinearSolve.NLSolver{OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, true, Vector{Float64}, Float64, Nothing, Float64, OrdinaryDiffEqNonlinearSolve.NLNewtonCache{Vector{Float64}, Float64, Float64, Vector{Float64}, Matrix{Float64}, Matrix{Float64}, SciMLBase.UJacobianWrapper{true, SciMLBase.ODEFunction{true, true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x67957fcf, 0xde1396e6, 0xf3fda331, 0xb01c0719, 0xe33e37e3), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xdf32e04c, 0x39d89b79, 0x618fc0fd, 0x44e9f60d, 0x94b90109), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xcf0c5d7f, 0x6e27a42b, 0xdd85b0d6, 0x85601580, 0x710ecab7), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xa1574565, 0x91efc8e9, 0x7a603f3f, 0x9970dfa2, 0x3a16d698), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Float64, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}}, jcType, LinearSolve.LinearCache{Matrix{Float64}, Vector{Float64}, Vector{Float64}, SciMLBase.NullParameters, LinearSolve.DefaultLinearSolver, LinearSolve.DefaultLinearSolverInit{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, LinearAlgebra.QRCompactWY{Float64, Matrix{Float64}, Matrix{Float64}}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Vector{Int64}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Vector{Int64}}, Nothing, Nothing, Nothing, LinearAlgebra.SVD{Float64, Float64, Matrix{Float64}, Vector{Float64}}, LinearAlgebra.Cholesky{Float64, Matrix{Float64}}, LinearAlgebra.Cholesky{Float64, Matrix{Float64}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int32}}, Base.RefValue{Int32}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Base.RefValue{Int64}}, LinearAlgebra.QRPivoted{Float64, Matrix{Float64}, Vector{Float64}, Vector{Int64}}, Nothing, Nothing, Nothing, Nothing, Nothing}, LinearSolve.InvPreconditioner{LinearAlgebra.Diagonal{Float64, Vector{Float64}}}, LinearAlgebra.Diagonal{Float64, Vector{Float64}}, Float64, Bool, LinearSolve.LinearSolveAdjoint{Missing}}}, Float64} where jcType<:Tuple{DifferentiationInterfaceForwardDiffExt.ForwardDiffTwoArgJacobianPrep{Nothing, C, Tuple{}} where C<:(ForwardDiff.JacobianConfig{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A, <:Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A, Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A}} where _A), DifferentiationInterfaceForwardDiffExt.ForwardDiffTwoArgJacobianPrep{Nothing, C, Tuple{}} where C<:(ForwardDiff.JacobianConfig{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A, <:Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A, Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A}} where _A)}))}
@time mmp_g = solve(EnsembleProblem(prob_g; prob_func=alter_dpsi), alg, ealg; trajectories=length(dpsirange), abstol=1e-8, reltol=1e-8)
1.671700 seconds (5.52 M allocations: 343.800 MiB, 7.99% gc time, 47.46% compilation time)
EnsembleSolution Solution of length 101 with uType:
SciMLBase.NonlinearSolution{Float64, 1, Vector{Float64}, Nothing, SciMLBase.SteadyStateProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xfac824a3, 0xf66617f8, 0x65c79932, 0x51078015, 0x456b4912), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x1de632bf, 0x4cc4145a, 0x17443c5a, 0x7e1e58d0, 0x976e0242), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xf4923f26, 0x124b6df7, 0x19d61b14, 0xc16b05da, 0xb6227c9d), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{Any}}}}, Val{true}}, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}}, Nothing, Nothing, Nothing, Nothing, Nothing}
MMP vs NADH turnover#
xs = dpsirange
ys = hcat(extract(mmp_g, sys_g.vNADHC1), extract(mmp_m, sys_m.vNADHC1), extract(mmp_q, sys_q.vNADHC1))
plot(xs, ys, xlabel="MMP (mV)", ylabel="NADH rate (mM/s)", label=["Gauthier" "Markevich" "Q site"]) |> PNG
MMP vs Q site status#
xs = dpsirange
ys = stack(extract.(Ref(mmp_q), [sys_q.Q_C1, sys_q.SQ_C1, sys_q.QH2_C1, sys_q.I_C1]), dims=2)
pl1 = plot(xs, ys, xlabel="MMP (mV)", ylabel="Concentration", label=["Q_C1" "SQ_C1" "QH2_C1" "I_C1"], title="Q site model", legend=:left, ylims=(0, 17μM))
ys2 = stack(extract.(Ref(mmp_m), [sys_m.Q_C1, sys_m.SQ_C1, sys_m.QH2_C1, sys_m.Iq_C1]), dims=2)
pl2 = plot(xs, ys, xlabel="MMP (mV)", ylabel="Concentration", label=["Q_C1" "SQ_C1" "QH2_C1" "I_C1"], title="M model", ylims=(0, 17μM))
plot(pl1, pl2) |> PNG
MMP vs Flavin site status#
xs = dpsirange
ys = stack(extract.(Ref(mmp_q), [sys_q.FMN, sys_q.FMNsq, sys_q.FMNH, sys_q.FMN_NAD, sys_q.FMNH_NADH, sys_q.FMN_NADH, sys_q.FMNH_NAD]), dims=2)
pl1 = plot(xs, ys, xlabel="MMP (mV)", ylabel="Concentration", label=["FMN" "FMNsq" "FMNH" "FMN_NAD" "FMNH_NADH" "FMN_NADH" "FMNH_NAD"], title="Q site model", legend=:right)
ys = stack(extract.(Ref(mmp_m), [sys_m.FMN, sys_m.FMNsq, sys_m.FMNH, sys_m.FMN_NAD, sys_m.FMNH_NADH, sys_m.FMN_NADH, sys_m.FMNH_NAD]), dims=2)
pl2 = plot(xs, ys, xlabel="MMP (mV)", ylabel="Concentration", label=["FMN" "FMNsq" "FMNH" "FMN_NAD" "FMNH_NADH" "FMN_NADH" "FMNH_NAD"], title="M model", legend=:right)
plot(pl1, pl2) |> PNG
MMP vs ROS production#
xs = dpsirange
ys_g = extract(mmp_g, sys_g.vROSC1)
ys_m = extract(mmp_m, sys_m.vROSC1)
ys_q = extract(mmp_q, sys_q.vROSC1)
plot(xs, [ys_g ys_m ys_q], xlabel="MMP (mV)", ylabel="ROS production (mM/s)", label=["Gauthier" "Markevich" "Q site"]) |> PNG
Varying NADH#
Simulations#
nadhrange = 10μM:10μM:2990μM
alter_nadh = (prob, i, repeat) -> begin
prob.ps[nadh] = nadhrange[i]
prob.ps[nad] = 3000μM - prob.ps[nadh]
prob
end
#10 (generic function with 1 method)
@time nad_q = solve(EnsembleProblem(prob_q; prob_func=alter_nadh), alg, ealg; trajectories=length(nadhrange), abstol=1e-8, reltol=1e-8)
2.421357 seconds (7.20 M allocations: 370.424 MiB, 7.33% gc time, 23.28% compilation time)
EnsembleSolution Solution of length 299 with uType:
Union{SciMLBase.NonlinearSolution{Float64, 1, Vector{Float64}, Vector{Float64}, SciMLBase.SteadyStateProblem{Vector{Float64}, true, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xc7e7a5fb, 0x0547168e, 0x5240d75e, 0xf96dfe59, 0x32e41e5a), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xeba74dd5, 0xd4c855f8, 0x618377dc, 0x6abe5830, 0x269334b1), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xe45f9644, 0xd2b45374, 0xeb266526, 0x51d5e17c, 0x03b62279), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xd9efa69c, 0xc30d7ef0, 0x1f35a64f, 0x8a780b3b, 0x62be22b7), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}}, SteadyStateDiffEq.DynamicSS{OrdinaryDiffEqSDIRK.TRBDF2{0, ADTypes.AutoForwardDiff{nothing, ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}}, Nothing, OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, typeof(OrdinaryDiffEqCore.DEFAULT_PRECS), Val{:forward}(), true, nothing, typeof(OrdinaryDiffEqCore.trivial_limiter!)}, Float64}, SciMLBase.ODESolution{Float64, 2, Vector{Vector{Float64}}, Nothing, Nothing, Vector{Float64}, Vector{Vector{Vector{Float64}}}, Nothing, SciMLBase.ODEProblem{Vector{Float64}, Tuple{Float64, Float64}, true, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.ODEFunction{true, true, SciMLBase.ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xc7e7a5fb, 0x0547168e, 0x5240d75e, 0xf96dfe59, 0x32e41e5a), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xeba74dd5, 0xd4c855f8, 0x618377dc, 0x6abe5830, 0x269334b1), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xe45f9644, 0xd2b45374, 0xeb266526, 0x51d5e17c, 0x03b62279), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xd9efa69c, 0xc30d7ef0, 0x1f35a64f, 0x8a780b3b, 0x62be22b7), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xe45f9644, 0xd2b45374, 0xeb266526, 0x51d5e17c, 0x03b62279), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xd9efa69c, 0xc30d7ef0, 0x1f35a64f, 0x8a780b3b, 0x62be22b7), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardODEProblem}, OrdinaryDiffEqSDIRK.TRBDF2{0, ADTypes.AutoForwardDiff{nothing, ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}}, Nothing, OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, typeof(OrdinaryDiffEqCore.DEFAULT_PRECS), Val{:forward}(), true, nothing, typeof(OrdinaryDiffEqCore.trivial_limiter!)}, OrdinaryDiffEqCore.InterpolationData{SciMLBase.ODEFunction{true, true, SciMLBase.ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xc7e7a5fb, 0x0547168e, 0x5240d75e, 0xf96dfe59, 0x32e41e5a), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xeba74dd5, 0xd4c855f8, 0x618377dc, 0x6abe5830, 0x269334b1), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xe45f9644, 0xd2b45374, 0xeb266526, 0x51d5e17c, 0x03b62279), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xd9efa69c, 0xc30d7ef0, 0x1f35a64f, 0x8a780b3b, 0x62be22b7), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xe45f9644, 0xd2b45374, 0xeb266526, 0x51d5e17c, 0x03b62279), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xd9efa69c, 0xc30d7ef0, 0x1f35a64f, 0x8a780b3b, 0x62be22b7), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Vector{Vector{Float64}}, Vector{Float64}, Vector{Vector{Vector{Float64}}}, Nothing, cacheType, Nothing}, SciMLBase.DEStats, Nothing, Nothing, Nothing, Nothing}, Nothing, Nothing, Nothing} where cacheType<:(OrdinaryDiffEqSDIRK.TRBDF2Cache{Vector{Float64}, Vector{Float64}, Vector{Float64}, OrdinaryDiffEqSDIRK.TRBDF2Tableau{Float64, Float64}, N, typeof(OrdinaryDiffEqCore.trivial_limiter!)} where N<:(OrdinaryDiffEqNonlinearSolve.NLSolver{OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, true, Vector{Float64}, Float64, Nothing, Float64, OrdinaryDiffEqNonlinearSolve.NLNewtonCache{Vector{Float64}, Float64, Float64, Vector{Float64}, Matrix{Float64}, Matrix{Float64}, SciMLBase.UJacobianWrapper{true, SciMLBase.ODEFunction{true, true, SciMLBase.ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xc7e7a5fb, 0x0547168e, 0x5240d75e, 0xf96dfe59, 0x32e41e5a), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xeba74dd5, 0xd4c855f8, 0x618377dc, 0x6abe5830, 0x269334b1), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xe45f9644, 0xd2b45374, 0xeb266526, 0x51d5e17c, 0x03b62279), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xd9efa69c, 0xc30d7ef0, 0x1f35a64f, 0x8a780b3b, 0x62be22b7), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xe45f9644, 0xd2b45374, 0xeb266526, 0x51d5e17c, 0x03b62279), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xd9efa69c, 0xc30d7ef0, 0x1f35a64f, 0x8a780b3b, 0x62be22b7), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Float64, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}}, jcType, LinearSolve.LinearCache{Matrix{Float64}, Vector{Float64}, Vector{Float64}, SciMLBase.NullParameters, LinearSolve.DefaultLinearSolver, LinearSolve.DefaultLinearSolverInit{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, LinearAlgebra.QRCompactWY{Float64, Matrix{Float64}, Matrix{Float64}}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Vector{Int64}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Vector{Int64}}, Nothing, Nothing, Nothing, LinearAlgebra.SVD{Float64, Float64, Matrix{Float64}, Vector{Float64}}, LinearAlgebra.Cholesky{Float64, Matrix{Float64}}, LinearAlgebra.Cholesky{Float64, Matrix{Float64}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int32}}, Base.RefValue{Int32}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Base.RefValue{Int64}}, LinearAlgebra.QRPivoted{Float64, Matrix{Float64}, Vector{Float64}, Vector{Int64}}, Nothing, Nothing, Nothing, Nothing, Nothing}, LinearSolve.InvPreconditioner{LinearAlgebra.Diagonal{Float64, Vector{Float64}}}, LinearAlgebra.Diagonal{Float64, Vector{Float64}}, Float64, Bool, LinearSolve.LinearSolveAdjoint{Missing}}}, Float64} where jcType<:Tuple{DifferentiationInterfaceForwardDiffExt.ForwardDiffTwoArgJacobianPrep{Nothing, C, Tuple{}} where C<:(ForwardDiff.JacobianConfig{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A, <:Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A, Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A}} where _A), DifferentiationInterfaceForwardDiffExt.ForwardDiffTwoArgJacobianPrep{Nothing, C, Tuple{}} where C<:(ForwardDiff.JacobianConfig{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A, <:Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A, Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A}} where _A)})), SciMLBase.NonlinearSolution{Float64, 1, Vector{Float64}, Vector{Float64}, SciMLBase.SteadyStateProblem{Vector{Float64}, true, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xc7e7a5fb, 0x0547168e, 0x5240d75e, 0xf96dfe59, 0x32e41e5a), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xeba74dd5, 0xd4c855f8, 0x618377dc, 0x6abe5830, 0x269334b1), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xe45f9644, 0xd2b45374, 0xeb266526, 0x51d5e17c, 0x03b62279), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xd9efa69c, 0xc30d7ef0, 0x1f35a64f, 0x8a780b3b, 0x62be22b7), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}}, SteadyStateDiffEq.DynamicSS{OrdinaryDiffEqSDIRK.TRBDF2{0, ADTypes.AutoForwardDiff{nothing, ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}}, Nothing, OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, typeof(OrdinaryDiffEqCore.DEFAULT_PRECS), Val{:forward}(), true, nothing, typeof(OrdinaryDiffEqCore.trivial_limiter!)}, Float64}, SciMLBase.ODESolution{Float64, 2, Vector{Vector{Float64}}, Nothing, Nothing, Vector{Float64}, Vector{Vector{Vector{Float64}}}, Nothing, SciMLBase.ODEProblem{Vector{Float64}, Tuple{Float64, Float64}, true, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.ODEFunction{true, true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xc7e7a5fb, 0x0547168e, 0x5240d75e, 0xf96dfe59, 0x32e41e5a), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xeba74dd5, 0xd4c855f8, 0x618377dc, 0x6abe5830, 0x269334b1), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xe45f9644, 0xd2b45374, 0xeb266526, 0x51d5e17c, 0x03b62279), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xd9efa69c, 0xc30d7ef0, 0x1f35a64f, 0x8a780b3b, 0x62be22b7), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardODEProblem}, OrdinaryDiffEqSDIRK.TRBDF2{0, ADTypes.AutoForwardDiff{nothing, ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}}, Nothing, OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, typeof(OrdinaryDiffEqCore.DEFAULT_PRECS), Val{:forward}(), true, nothing, typeof(OrdinaryDiffEqCore.trivial_limiter!)}, OrdinaryDiffEqCore.InterpolationData{SciMLBase.ODEFunction{true, true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xc7e7a5fb, 0x0547168e, 0x5240d75e, 0xf96dfe59, 0x32e41e5a), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xeba74dd5, 0xd4c855f8, 0x618377dc, 0x6abe5830, 0x269334b1), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xe45f9644, 0xd2b45374, 0xeb266526, 0x51d5e17c, 0x03b62279), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xd9efa69c, 0xc30d7ef0, 0x1f35a64f, 0x8a780b3b, 0x62be22b7), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Vector{Vector{Float64}}, Vector{Float64}, Vector{Vector{Vector{Float64}}}, Nothing, cacheType, Nothing}, SciMLBase.DEStats, Nothing, Nothing, Nothing, Nothing}, Nothing, Nothing, Nothing} where cacheType<:(OrdinaryDiffEqSDIRK.TRBDF2Cache{Vector{Float64}, Vector{Float64}, Vector{Float64}, OrdinaryDiffEqSDIRK.TRBDF2Tableau{Float64, Float64}, N, typeof(OrdinaryDiffEqCore.trivial_limiter!)} where N<:(OrdinaryDiffEqNonlinearSolve.NLSolver{OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, true, Vector{Float64}, Float64, Nothing, Float64, OrdinaryDiffEqNonlinearSolve.NLNewtonCache{Vector{Float64}, Float64, Float64, Vector{Float64}, Matrix{Float64}, Matrix{Float64}, SciMLBase.UJacobianWrapper{true, SciMLBase.ODEFunction{true, true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xc7e7a5fb, 0x0547168e, 0x5240d75e, 0xf96dfe59, 0x32e41e5a), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xeba74dd5, 0xd4c855f8, 0x618377dc, 0x6abe5830, 0x269334b1), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xe45f9644, 0xd2b45374, 0xeb266526, 0x51d5e17c, 0x03b62279), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xd9efa69c, 0xc30d7ef0, 0x1f35a64f, 0x8a780b3b, 0x62be22b7), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Float64, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}}, jcType, LinearSolve.LinearCache{Matrix{Float64}, Vector{Float64}, Vector{Float64}, SciMLBase.NullParameters, LinearSolve.DefaultLinearSolver, LinearSolve.DefaultLinearSolverInit{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, LinearAlgebra.QRCompactWY{Float64, Matrix{Float64}, Matrix{Float64}}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Vector{Int64}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Vector{Int64}}, Nothing, Nothing, Nothing, LinearAlgebra.SVD{Float64, Float64, Matrix{Float64}, Vector{Float64}}, LinearAlgebra.Cholesky{Float64, Matrix{Float64}}, LinearAlgebra.Cholesky{Float64, Matrix{Float64}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int32}}, Base.RefValue{Int32}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Base.RefValue{Int64}}, LinearAlgebra.QRPivoted{Float64, Matrix{Float64}, Vector{Float64}, Vector{Int64}}, Nothing, Nothing, Nothing, Nothing, Nothing}, LinearSolve.InvPreconditioner{LinearAlgebra.Diagonal{Float64, Vector{Float64}}}, LinearAlgebra.Diagonal{Float64, Vector{Float64}}, Float64, Bool, LinearSolve.LinearSolveAdjoint{Missing}}}, Float64} where jcType<:Tuple{DifferentiationInterfaceForwardDiffExt.ForwardDiffTwoArgJacobianPrep{Nothing, C, Tuple{}} where C<:(ForwardDiff.JacobianConfig{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A, <:Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A, Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A}} where _A), DifferentiationInterfaceForwardDiffExt.ForwardDiffTwoArgJacobianPrep{Nothing, C, Tuple{}} where C<:(ForwardDiff.JacobianConfig{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A, <:Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A, Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A}} where _A)}))}
@time nad_g = solve(EnsembleProblem(prob_g; prob_func=alter_nadh), alg, ealg; trajectories=length(nadhrange), abstol=1e-8, reltol=1e-8)
3.499071 seconds (12.00 M allocations: 793.419 MiB, 13.63% gc time, 19.91% compilation time)
EnsembleSolution Solution of length 299 with uType:
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@time nad_m = solve(EnsembleProblem(prob_m; prob_func=alter_nadh), alg, ealg; trajectories=length(nadhrange), abstol=1e-8, reltol=1e-8)
22.274694 seconds (34.58 M allocations: 5.456 GiB, 26.47% gc time, 2.86% compilation time)
EnsembleSolution Solution of length 299 with uType:
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ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}}, SteadyStateDiffEq.DynamicSS{OrdinaryDiffEqSDIRK.TRBDF2{0, ADTypes.AutoForwardDiff{nothing, ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}}, Nothing, OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, typeof(OrdinaryDiffEqCore.DEFAULT_PRECS), Val{:forward}(), true, nothing, typeof(OrdinaryDiffEqCore.trivial_limiter!)}, Float64}, SciMLBase.ODESolution{Float64, 2, Vector{Vector{Float64}}, Nothing, Nothing, Vector{Float64}, Vector{Vector{Vector{Float64}}}, Nothing, SciMLBase.ODEProblem{Vector{Float64}, Tuple{Float64, Float64}, true, ModelingToolkit.MTKParameters{Vector{Float64}, 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ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xcf0c5d7f, 0x6e27a42b, 0xdd85b0d6, 0x85601580, 0x710ecab7), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xa1574565, 0x91efc8e9, 0x7a603f3f, 0x9970dfa2, 0x3a16d698), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Vector{Vector{Float64}}, Vector{Float64}, Vector{Vector{Vector{Float64}}}, Nothing, cacheType, Nothing}, SciMLBase.DEStats, Nothing, Nothing, Nothing, Nothing}, Nothing, Nothing, Nothing} where cacheType<:(OrdinaryDiffEqSDIRK.TRBDF2Cache{Vector{Float64}, Vector{Float64}, Vector{Float64}, OrdinaryDiffEqSDIRK.TRBDF2Tableau{Float64, Float64}, N, typeof(OrdinaryDiffEqCore.trivial_limiter!)} where N<:(OrdinaryDiffEqNonlinearSolve.NLSolver{OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, true, Vector{Float64}, Float64, Nothing, Float64, OrdinaryDiffEqNonlinearSolve.NLNewtonCache{Vector{Float64}, Float64, Float64, Vector{Float64}, Matrix{Float64}, Matrix{Float64}, SciMLBase.UJacobianWrapper{true, SciMLBase.ODEFunction{true, true, SciMLBase.ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x67957fcf, 0xde1396e6, 0xf3fda331, 0xb01c0719, 0xe33e37e3), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xdf32e04c, 0x39d89b79, 0x618fc0fd, 0x44e9f60d, 0x94b90109), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xcf0c5d7f, 0x6e27a42b, 0xdd85b0d6, 0x85601580, 0x710ecab7), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xa1574565, 0x91efc8e9, 0x7a603f3f, 0x9970dfa2, 0x3a16d698), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xcf0c5d7f, 0x6e27a42b, 0xdd85b0d6, 0x85601580, 0x710ecab7), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xa1574565, 0x91efc8e9, 0x7a603f3f, 0x9970dfa2, 0x3a16d698), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Float64, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}}, jcType, LinearSolve.LinearCache{Matrix{Float64}, Vector{Float64}, Vector{Float64}, SciMLBase.NullParameters, LinearSolve.DefaultLinearSolver, LinearSolve.DefaultLinearSolverInit{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, LinearAlgebra.QRCompactWY{Float64, Matrix{Float64}, Matrix{Float64}}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Vector{Int64}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Vector{Int64}}, Nothing, Nothing, Nothing, LinearAlgebra.SVD{Float64, Float64, Matrix{Float64}, Vector{Float64}}, LinearAlgebra.Cholesky{Float64, Matrix{Float64}}, LinearAlgebra.Cholesky{Float64, Matrix{Float64}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int32}}, Base.RefValue{Int32}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Base.RefValue{Int64}}, LinearAlgebra.QRPivoted{Float64, Matrix{Float64}, Vector{Float64}, Vector{Int64}}, Nothing, Nothing, Nothing, Nothing, Nothing}, LinearSolve.InvPreconditioner{LinearAlgebra.Diagonal{Float64, Vector{Float64}}}, LinearAlgebra.Diagonal{Float64, Vector{Float64}}, Float64, Bool, LinearSolve.LinearSolveAdjoint{Missing}}}, Float64} where jcType<:Tuple{DifferentiationInterfaceForwardDiffExt.ForwardDiffTwoArgJacobianPrep{Nothing, C, Tuple{}} where C<:(ForwardDiff.JacobianConfig{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A, <:Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A, Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A}} where _A), DifferentiationInterfaceForwardDiffExt.ForwardDiffTwoArgJacobianPrep{Nothing, C, Tuple{}} where C<:(ForwardDiff.JacobianConfig{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A, <:Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A, Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A}} where _A)})), SciMLBase.NonlinearSolution{Float64, 1, Vector{Float64}, Vector{Float64}, SciMLBase.SteadyStateProblem{Vector{Float64}, true, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x67957fcf, 0xde1396e6, 0xf3fda331, 0xb01c0719, 0xe33e37e3), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xdf32e04c, 0x39d89b79, 0x618fc0fd, 0x44e9f60d, 0x94b90109), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xcf0c5d7f, 0x6e27a42b, 0xdd85b0d6, 0x85601580, 0x710ecab7), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xa1574565, 0x91efc8e9, 0x7a603f3f, 0x9970dfa2, 0x3a16d698), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}}, SteadyStateDiffEq.DynamicSS{OrdinaryDiffEqSDIRK.TRBDF2{0, ADTypes.AutoForwardDiff{nothing, ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}}, Nothing, OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, typeof(OrdinaryDiffEqCore.DEFAULT_PRECS), Val{:forward}(), true, nothing, typeof(OrdinaryDiffEqCore.trivial_limiter!)}, Float64}, SciMLBase.ODESolution{Float64, 2, Vector{Vector{Float64}}, Nothing, Nothing, Vector{Float64}, Vector{Vector{Vector{Float64}}}, Nothing, SciMLBase.ODEProblem{Vector{Float64}, Tuple{Float64, Float64}, true, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.ODEFunction{true, true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x67957fcf, 0xde1396e6, 0xf3fda331, 0xb01c0719, 0xe33e37e3), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xdf32e04c, 0x39d89b79, 0x618fc0fd, 0x44e9f60d, 0x94b90109), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xcf0c5d7f, 0x6e27a42b, 0xdd85b0d6, 0x85601580, 0x710ecab7), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xa1574565, 0x91efc8e9, 0x7a603f3f, 0x9970dfa2, 0x3a16d698), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardODEProblem}, OrdinaryDiffEqSDIRK.TRBDF2{0, ADTypes.AutoForwardDiff{nothing, ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}}, Nothing, OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, typeof(OrdinaryDiffEqCore.DEFAULT_PRECS), Val{:forward}(), true, nothing, typeof(OrdinaryDiffEqCore.trivial_limiter!)}, OrdinaryDiffEqCore.InterpolationData{SciMLBase.ODEFunction{true, true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x67957fcf, 0xde1396e6, 0xf3fda331, 0xb01c0719, 0xe33e37e3), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xdf32e04c, 0x39d89b79, 0x618fc0fd, 0x44e9f60d, 0x94b90109), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xcf0c5d7f, 0x6e27a42b, 0xdd85b0d6, 0x85601580, 0x710ecab7), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xa1574565, 0x91efc8e9, 0x7a603f3f, 0x9970dfa2, 0x3a16d698), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Vector{Vector{Float64}}, Vector{Float64}, Vector{Vector{Vector{Float64}}}, Nothing, cacheType, Nothing}, SciMLBase.DEStats, Nothing, Nothing, Nothing, Nothing}, Nothing, Nothing, Nothing} where cacheType<:(OrdinaryDiffEqSDIRK.TRBDF2Cache{Vector{Float64}, Vector{Float64}, Vector{Float64}, OrdinaryDiffEqSDIRK.TRBDF2Tableau{Float64, Float64}, N, typeof(OrdinaryDiffEqCore.trivial_limiter!)} where N<:(OrdinaryDiffEqNonlinearSolve.NLSolver{OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, true, Vector{Float64}, Float64, Nothing, Float64, OrdinaryDiffEqNonlinearSolve.NLNewtonCache{Vector{Float64}, Float64, Float64, Vector{Float64}, Matrix{Float64}, Matrix{Float64}, SciMLBase.UJacobianWrapper{true, SciMLBase.ODEFunction{true, true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x67957fcf, 0xde1396e6, 0xf3fda331, 0xb01c0719, 0xe33e37e3), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xdf32e04c, 0x39d89b79, 0x618fc0fd, 0x44e9f60d, 0x94b90109), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xcf0c5d7f, 0x6e27a42b, 0xdd85b0d6, 0x85601580, 0x710ecab7), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xa1574565, 0x91efc8e9, 0x7a603f3f, 0x9970dfa2, 0x3a16d698), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Float64, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}}, jcType, LinearSolve.LinearCache{Matrix{Float64}, Vector{Float64}, Vector{Float64}, SciMLBase.NullParameters, LinearSolve.DefaultLinearSolver, LinearSolve.DefaultLinearSolverInit{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, LinearAlgebra.QRCompactWY{Float64, Matrix{Float64}, Matrix{Float64}}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Vector{Int64}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Vector{Int64}}, Nothing, Nothing, Nothing, LinearAlgebra.SVD{Float64, Float64, Matrix{Float64}, Vector{Float64}}, LinearAlgebra.Cholesky{Float64, Matrix{Float64}}, LinearAlgebra.Cholesky{Float64, Matrix{Float64}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int32}}, Base.RefValue{Int32}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Base.RefValue{Int64}}, LinearAlgebra.QRPivoted{Float64, Matrix{Float64}, Vector{Float64}, Vector{Int64}}, Nothing, Nothing, Nothing, Nothing, Nothing}, LinearSolve.InvPreconditioner{LinearAlgebra.Diagonal{Float64, Vector{Float64}}}, LinearAlgebra.Diagonal{Float64, Vector{Float64}}, Float64, Bool, LinearSolve.LinearSolveAdjoint{Missing}}}, Float64} where jcType<:Tuple{DifferentiationInterfaceForwardDiffExt.ForwardDiffTwoArgJacobianPrep{Nothing, C, Tuple{}} where C<:(ForwardDiff.JacobianConfig{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A, <:Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A, Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A}} where _A), DifferentiationInterfaceForwardDiffExt.ForwardDiffTwoArgJacobianPrep{Nothing, C, Tuple{}} where C<:(ForwardDiff.JacobianConfig{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A, <:Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A, Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A}} where _A)}))}
NADH vs turnover#
xs = nadhrange
ys_g = extract(nad_g, sys_g.vNADHC1)
ys_m = extract(nad_m, sys_m.vNADHC1)
ys_q = extract(nad_q, sys_q.vNADHC1)
plot(xs, [ys_g ys_m ys_q], xlabel="NADH (μM)", ylabel="NADH rate (mM/s)", label=["Gauthier" "Markevich" "Q site"]) |> PNG
xs = nadhrange
ys = [extract(nad_m, sys_m.N2r_C1) extract(nad_q, sys_q.N2r_C1)] ./ μM
plot(xs, ys, xlabel="NADH (μM)", ylabel="Reduced N2 (μM)", label=["Markevich" "Q site"]) |> PNG
NADH vs ROS production#
xs = nadhrange
ys = [extract(nad_g, sys_g.vROSC1) extract(nad_m, sys_m.vROSC1) extract(nad_q, sys_q.vROSC1)]
plot(xs, ys, xlabel="NADH (μM)", ylabel="ROS production (mM/s)", label=["Gauthier" "Markevich" "Q site"]) |> PNG
xs = nadhrange
ys = stack(extract.(Ref(nad_q), [sys_q.Q_C1, sys_q.SQ_C1, sys_q.QH2_C1, sys_q.I_C1]), dims=2)
pl1 = plot(xs, ys, xlabel="NADH (μM)", ylabel="Concentration (μM)", label=["Q_C1" "SQ_C1" "QH2_C1" "I_C1"], title="Q site", legend=:top, ylims=(0, 17))
ys = stack(extract.(Ref(nad_m), [sys_m.Q_C1, sys_m.SQ_C1, sys_m.QH2_C1, sys_m.Iq_C1]), dims=2)
pl2 = plot(xs, ys, xlabel="NADH (μM)", ylabel="Concentration", label=["Q_C1" "SQ_C1" "QH2_C1" "I_C1"], title="M model", ylims=(0, 17))
plot(pl1, pl2) |> PNG
Varying Q/QH2#
Simulations#
qh2range = 10μM:10μM:1990μM
alter_qh2 = (prob, i, repeat) -> begin
prob.ps[QH2_n] = qh2range[i]
prob.ps[Q_n] = 2000μM - prob.ps[QH2_n]
prob
end
#13 (generic function with 1 method)
@time qh2_q = solve(EnsembleProblem(prob_q; prob_func=alter_qh2), alg, ealg; trajectories=length(qh2range), abstol=1e-8, reltol=1e-8)
1.551317 seconds (4.71 M allocations: 242.663 MiB, 4.85% gc time, 21.66% compilation time)
EnsembleSolution Solution of length 199 with uType:
Union{SciMLBase.NonlinearSolution{Float64, 1, Vector{Float64}, Vector{Float64}, SciMLBase.SteadyStateProblem{Vector{Float64}, true, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xc7e7a5fb, 0x0547168e, 0x5240d75e, 0xf96dfe59, 0x32e41e5a), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xeba74dd5, 0xd4c855f8, 0x618377dc, 0x6abe5830, 0x269334b1), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xe45f9644, 0xd2b45374, 0xeb266526, 0x51d5e17c, 0x03b62279), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xd9efa69c, 0xc30d7ef0, 0x1f35a64f, 0x8a780b3b, 0x62be22b7), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}}, SteadyStateDiffEq.DynamicSS{OrdinaryDiffEqSDIRK.TRBDF2{0, ADTypes.AutoForwardDiff{nothing, ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}}, Nothing, OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, typeof(OrdinaryDiffEqCore.DEFAULT_PRECS), Val{:forward}(), true, nothing, typeof(OrdinaryDiffEqCore.trivial_limiter!)}, Float64}, SciMLBase.ODESolution{Float64, 2, Vector{Vector{Float64}}, Nothing, Nothing, Vector{Float64}, Vector{Vector{Vector{Float64}}}, Nothing, SciMLBase.ODEProblem{Vector{Float64}, Tuple{Float64, Float64}, true, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.ODEFunction{true, true, SciMLBase.ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xc7e7a5fb, 0x0547168e, 0x5240d75e, 0xf96dfe59, 0x32e41e5a), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xeba74dd5, 0xd4c855f8, 0x618377dc, 0x6abe5830, 0x269334b1), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xe45f9644, 0xd2b45374, 0xeb266526, 0x51d5e17c, 0x03b62279), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xd9efa69c, 0xc30d7ef0, 0x1f35a64f, 0x8a780b3b, 0x62be22b7), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xe45f9644, 0xd2b45374, 0xeb266526, 0x51d5e17c, 0x03b62279), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xd9efa69c, 0xc30d7ef0, 0x1f35a64f, 0x8a780b3b, 0x62be22b7), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardODEProblem}, OrdinaryDiffEqSDIRK.TRBDF2{0, ADTypes.AutoForwardDiff{nothing, ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}}, Nothing, OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, typeof(OrdinaryDiffEqCore.DEFAULT_PRECS), Val{:forward}(), true, nothing, typeof(OrdinaryDiffEqCore.trivial_limiter!)}, OrdinaryDiffEqCore.InterpolationData{SciMLBase.ODEFunction{true, true, SciMLBase.ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xc7e7a5fb, 0x0547168e, 0x5240d75e, 0xf96dfe59, 0x32e41e5a), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xeba74dd5, 0xd4c855f8, 0x618377dc, 0x6abe5830, 0x269334b1), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xe45f9644, 0xd2b45374, 0xeb266526, 0x51d5e17c, 0x03b62279), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xd9efa69c, 0xc30d7ef0, 0x1f35a64f, 0x8a780b3b, 0x62be22b7), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xe45f9644, 0xd2b45374, 0xeb266526, 0x51d5e17c, 0x03b62279), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xd9efa69c, 0xc30d7ef0, 0x1f35a64f, 0x8a780b3b, 0x62be22b7), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Vector{Vector{Float64}}, Vector{Float64}, Vector{Vector{Vector{Float64}}}, Nothing, cacheType, Nothing}, SciMLBase.DEStats, Nothing, Nothing, Nothing, Nothing}, Nothing, Nothing, Nothing} where cacheType<:(OrdinaryDiffEqSDIRK.TRBDF2Cache{Vector{Float64}, Vector{Float64}, Vector{Float64}, OrdinaryDiffEqSDIRK.TRBDF2Tableau{Float64, Float64}, N, typeof(OrdinaryDiffEqCore.trivial_limiter!)} where N<:(OrdinaryDiffEqNonlinearSolve.NLSolver{OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, true, Vector{Float64}, Float64, Nothing, Float64, OrdinaryDiffEqNonlinearSolve.NLNewtonCache{Vector{Float64}, Float64, Float64, Vector{Float64}, Matrix{Float64}, Matrix{Float64}, SciMLBase.UJacobianWrapper{true, SciMLBase.ODEFunction{true, true, SciMLBase.ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xc7e7a5fb, 0x0547168e, 0x5240d75e, 0xf96dfe59, 0x32e41e5a), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xeba74dd5, 0xd4c855f8, 0x618377dc, 0x6abe5830, 0x269334b1), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xe45f9644, 0xd2b45374, 0xeb266526, 0x51d5e17c, 0x03b62279), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xd9efa69c, 0xc30d7ef0, 0x1f35a64f, 0x8a780b3b, 0x62be22b7), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xe45f9644, 0xd2b45374, 0xeb266526, 0x51d5e17c, 0x03b62279), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xd9efa69c, 0xc30d7ef0, 0x1f35a64f, 0x8a780b3b, 0x62be22b7), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Float64, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}}, jcType, LinearSolve.LinearCache{Matrix{Float64}, Vector{Float64}, Vector{Float64}, SciMLBase.NullParameters, LinearSolve.DefaultLinearSolver, LinearSolve.DefaultLinearSolverInit{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, LinearAlgebra.QRCompactWY{Float64, Matrix{Float64}, Matrix{Float64}}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Vector{Int64}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Vector{Int64}}, Nothing, Nothing, Nothing, LinearAlgebra.SVD{Float64, Float64, Matrix{Float64}, Vector{Float64}}, LinearAlgebra.Cholesky{Float64, Matrix{Float64}}, LinearAlgebra.Cholesky{Float64, Matrix{Float64}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int32}}, Base.RefValue{Int32}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Base.RefValue{Int64}}, LinearAlgebra.QRPivoted{Float64, Matrix{Float64}, Vector{Float64}, Vector{Int64}}, Nothing, Nothing, Nothing, Nothing, Nothing}, LinearSolve.InvPreconditioner{LinearAlgebra.Diagonal{Float64, Vector{Float64}}}, LinearAlgebra.Diagonal{Float64, Vector{Float64}}, Float64, Bool, LinearSolve.LinearSolveAdjoint{Missing}}}, Float64} where jcType<:Tuple{DifferentiationInterfaceForwardDiffExt.ForwardDiffTwoArgJacobianPrep{Nothing, C, Tuple{}} where C<:(ForwardDiff.JacobianConfig{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A, <:Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A, Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A}} where _A), DifferentiationInterfaceForwardDiffExt.ForwardDiffTwoArgJacobianPrep{Nothing, C, Tuple{}} where C<:(ForwardDiff.JacobianConfig{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A, <:Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A, Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A}} where _A)})), SciMLBase.NonlinearSolution{Float64, 1, Vector{Float64}, Vector{Float64}, SciMLBase.SteadyStateProblem{Vector{Float64}, true, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xc7e7a5fb, 0x0547168e, 0x5240d75e, 0xf96dfe59, 0x32e41e5a), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xeba74dd5, 0xd4c855f8, 0x618377dc, 0x6abe5830, 0x269334b1), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xe45f9644, 0xd2b45374, 0xeb266526, 0x51d5e17c, 0x03b62279), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xd9efa69c, 0xc30d7ef0, 0x1f35a64f, 0x8a780b3b, 0x62be22b7), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}}, SteadyStateDiffEq.DynamicSS{OrdinaryDiffEqSDIRK.TRBDF2{0, ADTypes.AutoForwardDiff{nothing, ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}}, Nothing, OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, typeof(OrdinaryDiffEqCore.DEFAULT_PRECS), Val{:forward}(), true, nothing, typeof(OrdinaryDiffEqCore.trivial_limiter!)}, Float64}, SciMLBase.ODESolution{Float64, 2, Vector{Vector{Float64}}, Nothing, Nothing, Vector{Float64}, Vector{Vector{Vector{Float64}}}, Nothing, SciMLBase.ODEProblem{Vector{Float64}, Tuple{Float64, Float64}, true, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.ODEFunction{true, true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xc7e7a5fb, 0x0547168e, 0x5240d75e, 0xf96dfe59, 0x32e41e5a), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xeba74dd5, 0xd4c855f8, 0x618377dc, 0x6abe5830, 0x269334b1), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xe45f9644, 0xd2b45374, 0xeb266526, 0x51d5e17c, 0x03b62279), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xd9efa69c, 0xc30d7ef0, 0x1f35a64f, 0x8a780b3b, 0x62be22b7), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardODEProblem}, OrdinaryDiffEqSDIRK.TRBDF2{0, ADTypes.AutoForwardDiff{nothing, ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}}, Nothing, OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, typeof(OrdinaryDiffEqCore.DEFAULT_PRECS), Val{:forward}(), true, nothing, typeof(OrdinaryDiffEqCore.trivial_limiter!)}, OrdinaryDiffEqCore.InterpolationData{SciMLBase.ODEFunction{true, true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xc7e7a5fb, 0x0547168e, 0x5240d75e, 0xf96dfe59, 0x32e41e5a), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xeba74dd5, 0xd4c855f8, 0x618377dc, 0x6abe5830, 0x269334b1), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xe45f9644, 0xd2b45374, 0xeb266526, 0x51d5e17c, 0x03b62279), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xd9efa69c, 0xc30d7ef0, 0x1f35a64f, 0x8a780b3b, 0x62be22b7), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Vector{Vector{Float64}}, Vector{Float64}, Vector{Vector{Vector{Float64}}}, Nothing, cacheType, Nothing}, SciMLBase.DEStats, Nothing, Nothing, Nothing, Nothing}, Nothing, Nothing, Nothing} where cacheType<:(OrdinaryDiffEqSDIRK.TRBDF2Cache{Vector{Float64}, Vector{Float64}, Vector{Float64}, OrdinaryDiffEqSDIRK.TRBDF2Tableau{Float64, Float64}, N, typeof(OrdinaryDiffEqCore.trivial_limiter!)} where N<:(OrdinaryDiffEqNonlinearSolve.NLSolver{OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, true, Vector{Float64}, Float64, Nothing, Float64, OrdinaryDiffEqNonlinearSolve.NLNewtonCache{Vector{Float64}, Float64, Float64, Vector{Float64}, Matrix{Float64}, Matrix{Float64}, SciMLBase.UJacobianWrapper{true, SciMLBase.ODEFunction{true, true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xc7e7a5fb, 0x0547168e, 0x5240d75e, 0xf96dfe59, 0x32e41e5a), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xeba74dd5, 0xd4c855f8, 0x618377dc, 0x6abe5830, 0x269334b1), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xe45f9644, 0xd2b45374, 0xeb266526, 0x51d5e17c, 0x03b62279), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xd9efa69c, 0xc30d7ef0, 0x1f35a64f, 0x8a780b3b, 0x62be22b7), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Float64, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}}, jcType, LinearSolve.LinearCache{Matrix{Float64}, Vector{Float64}, Vector{Float64}, SciMLBase.NullParameters, LinearSolve.DefaultLinearSolver, LinearSolve.DefaultLinearSolverInit{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, LinearAlgebra.QRCompactWY{Float64, Matrix{Float64}, Matrix{Float64}}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Vector{Int64}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Vector{Int64}}, Nothing, Nothing, Nothing, LinearAlgebra.SVD{Float64, Float64, Matrix{Float64}, Vector{Float64}}, LinearAlgebra.Cholesky{Float64, Matrix{Float64}}, LinearAlgebra.Cholesky{Float64, Matrix{Float64}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int32}}, Base.RefValue{Int32}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Base.RefValue{Int64}}, LinearAlgebra.QRPivoted{Float64, Matrix{Float64}, Vector{Float64}, Vector{Int64}}, Nothing, Nothing, Nothing, Nothing, Nothing}, LinearSolve.InvPreconditioner{LinearAlgebra.Diagonal{Float64, Vector{Float64}}}, LinearAlgebra.Diagonal{Float64, Vector{Float64}}, Float64, Bool, LinearSolve.LinearSolveAdjoint{Missing}}}, Float64} where jcType<:Tuple{DifferentiationInterfaceForwardDiffExt.ForwardDiffTwoArgJacobianPrep{Nothing, C, Tuple{}} where C<:(ForwardDiff.JacobianConfig{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A, <:Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A, Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A}} where _A), DifferentiationInterfaceForwardDiffExt.ForwardDiffTwoArgJacobianPrep{Nothing, C, Tuple{}} where C<:(ForwardDiff.JacobianConfig{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A, <:Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A, Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A}} where _A)}))}
@time qh2_g = solve(EnsembleProblem(prob_g; prob_func=alter_qh2), alg, ealg; trajectories=length(qh2range), abstol=1e-8, reltol=1e-8)
2.390562 seconds (8.06 M allocations: 531.656 MiB, 12.07% gc time, 15.89% compilation time)
EnsembleSolution Solution of length 199 with uType:
SciMLBase.NonlinearSolution{Float64, 1, Vector{Float64}, Nothing, SciMLBase.SteadyStateProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xfac824a3, 0xf66617f8, 0x65c79932, 0x51078015, 0x456b4912), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x1de632bf, 0x4cc4145a, 0x17443c5a, 0x7e1e58d0, 0x976e0242), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xf4923f26, 0x124b6df7, 0x19d61b14, 0xc16b05da, 0xb6227c9d), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{Any}}}}, Val{true}}, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}}, Nothing, Nothing, Nothing, Nothing, Nothing}
@time qh2_m = solve(EnsembleProblem(prob_m; prob_func=alter_qh2), alg, ealg; trajectories=length(qh2range), abstol=1e-8, reltol=1e-8)
20.806652 seconds (35.25 M allocations: 6.082 GiB, 22.81% gc time, 1.66% compilation time)
EnsembleSolution Solution of length 199 with uType:
Union{SciMLBase.NonlinearSolution{Float64, 1, Vector{Float64}, Vector{Float64}, SciMLBase.SteadyStateProblem{Vector{Float64}, true, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x67957fcf, 0xde1396e6, 0xf3fda331, 0xb01c0719, 0xe33e37e3), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xdf32e04c, 0x39d89b79, 0x618fc0fd, 0x44e9f60d, 0x94b90109), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xcf0c5d7f, 0x6e27a42b, 0xdd85b0d6, 0x85601580, 0x710ecab7), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xa1574565, 0x91efc8e9, 0x7a603f3f, 0x9970dfa2, 0x3a16d698), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}}, SteadyStateDiffEq.DynamicSS{OrdinaryDiffEqSDIRK.TRBDF2{0, ADTypes.AutoForwardDiff{nothing, ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}}, Nothing, OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, typeof(OrdinaryDiffEqCore.DEFAULT_PRECS), Val{:forward}(), true, nothing, typeof(OrdinaryDiffEqCore.trivial_limiter!)}, Float64}, SciMLBase.ODESolution{Float64, 2, Vector{Vector{Float64}}, Nothing, Nothing, Vector{Float64}, Vector{Vector{Vector{Float64}}}, Nothing, SciMLBase.ODEProblem{Vector{Float64}, Tuple{Float64, Float64}, true, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.ODEFunction{true, true, SciMLBase.ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x67957fcf, 0xde1396e6, 0xf3fda331, 0xb01c0719, 0xe33e37e3), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xdf32e04c, 0x39d89b79, 0x618fc0fd, 0x44e9f60d, 0x94b90109), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xcf0c5d7f, 0x6e27a42b, 0xdd85b0d6, 0x85601580, 0x710ecab7), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xa1574565, 0x91efc8e9, 0x7a603f3f, 0x9970dfa2, 0x3a16d698), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xcf0c5d7f, 0x6e27a42b, 0xdd85b0d6, 0x85601580, 0x710ecab7), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xa1574565, 0x91efc8e9, 0x7a603f3f, 0x9970dfa2, 0x3a16d698), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardODEProblem}, OrdinaryDiffEqSDIRK.TRBDF2{0, ADTypes.AutoForwardDiff{nothing, ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}}, Nothing, OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, typeof(OrdinaryDiffEqCore.DEFAULT_PRECS), Val{:forward}(), true, nothing, typeof(OrdinaryDiffEqCore.trivial_limiter!)}, OrdinaryDiffEqCore.InterpolationData{SciMLBase.ODEFunction{true, true, SciMLBase.ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, 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ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xcf0c5d7f, 0x6e27a42b, 0xdd85b0d6, 0x85601580, 0x710ecab7), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xa1574565, 0x91efc8e9, 0x7a603f3f, 0x9970dfa2, 0x3a16d698), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xcf0c5d7f, 0x6e27a42b, 0xdd85b0d6, 0x85601580, 0x710ecab7), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xa1574565, 0x91efc8e9, 0x7a603f3f, 0x9970dfa2, 0x3a16d698), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Vector{Vector{Float64}}, Vector{Float64}, Vector{Vector{Vector{Float64}}}, Nothing, cacheType, Nothing}, SciMLBase.DEStats, Nothing, Nothing, Nothing, Nothing}, Nothing, Nothing, Nothing} where cacheType<:(OrdinaryDiffEqSDIRK.TRBDF2Cache{Vector{Float64}, Vector{Float64}, Vector{Float64}, OrdinaryDiffEqSDIRK.TRBDF2Tableau{Float64, Float64}, N, typeof(OrdinaryDiffEqCore.trivial_limiter!)} where N<:(OrdinaryDiffEqNonlinearSolve.NLSolver{OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, true, Vector{Float64}, Float64, Nothing, Float64, OrdinaryDiffEqNonlinearSolve.NLNewtonCache{Vector{Float64}, Float64, Float64, Vector{Float64}, Matrix{Float64}, Matrix{Float64}, SciMLBase.UJacobianWrapper{true, SciMLBase.ODEFunction{true, true, SciMLBase.ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x67957fcf, 0xde1396e6, 0xf3fda331, 0xb01c0719, 0xe33e37e3), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xdf32e04c, 0x39d89b79, 0x618fc0fd, 0x44e9f60d, 0x94b90109), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xcf0c5d7f, 0x6e27a42b, 0xdd85b0d6, 0x85601580, 0x710ecab7), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xa1574565, 0x91efc8e9, 0x7a603f3f, 0x9970dfa2, 0x3a16d698), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xcf0c5d7f, 0x6e27a42b, 0xdd85b0d6, 0x85601580, 0x710ecab7), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xa1574565, 0x91efc8e9, 0x7a603f3f, 0x9970dfa2, 0x3a16d698), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Float64, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}}, jcType, LinearSolve.LinearCache{Matrix{Float64}, Vector{Float64}, Vector{Float64}, SciMLBase.NullParameters, LinearSolve.DefaultLinearSolver, LinearSolve.DefaultLinearSolverInit{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, LinearAlgebra.QRCompactWY{Float64, Matrix{Float64}, Matrix{Float64}}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Vector{Int64}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Vector{Int64}}, Nothing, Nothing, Nothing, LinearAlgebra.SVD{Float64, Float64, Matrix{Float64}, Vector{Float64}}, LinearAlgebra.Cholesky{Float64, Matrix{Float64}}, LinearAlgebra.Cholesky{Float64, Matrix{Float64}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int32}}, Base.RefValue{Int32}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Base.RefValue{Int64}}, LinearAlgebra.QRPivoted{Float64, Matrix{Float64}, Vector{Float64}, Vector{Int64}}, Nothing, Nothing, Nothing, Nothing, Nothing}, LinearSolve.InvPreconditioner{LinearAlgebra.Diagonal{Float64, Vector{Float64}}}, LinearAlgebra.Diagonal{Float64, Vector{Float64}}, Float64, Bool, LinearSolve.LinearSolveAdjoint{Missing}}}, Float64} where jcType<:Tuple{DifferentiationInterfaceForwardDiffExt.ForwardDiffTwoArgJacobianPrep{Nothing, C, Tuple{}} where C<:(ForwardDiff.JacobianConfig{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A, <:Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A, Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A}} where _A), DifferentiationInterfaceForwardDiffExt.ForwardDiffTwoArgJacobianPrep{Nothing, C, Tuple{}} where C<:(ForwardDiff.JacobianConfig{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A, <:Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A, Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A}} where _A)})), SciMLBase.NonlinearSolution{Float64, 1, Vector{Float64}, Vector{Float64}, SciMLBase.SteadyStateProblem{Vector{Float64}, true, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x67957fcf, 0xde1396e6, 0xf3fda331, 0xb01c0719, 0xe33e37e3), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xdf32e04c, 0x39d89b79, 0x618fc0fd, 0x44e9f60d, 0x94b90109), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xcf0c5d7f, 0x6e27a42b, 0xdd85b0d6, 0x85601580, 0x710ecab7), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xa1574565, 0x91efc8e9, 0x7a603f3f, 0x9970dfa2, 0x3a16d698), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}}, SteadyStateDiffEq.DynamicSS{OrdinaryDiffEqSDIRK.TRBDF2{0, ADTypes.AutoForwardDiff{nothing, ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}}, Nothing, OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, typeof(OrdinaryDiffEqCore.DEFAULT_PRECS), Val{:forward}(), true, nothing, typeof(OrdinaryDiffEqCore.trivial_limiter!)}, Float64}, SciMLBase.ODESolution{Float64, 2, Vector{Vector{Float64}}, Nothing, Nothing, Vector{Float64}, Vector{Vector{Vector{Float64}}}, Nothing, SciMLBase.ODEProblem{Vector{Float64}, Tuple{Float64, Float64}, true, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.ODEFunction{true, true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x67957fcf, 0xde1396e6, 0xf3fda331, 0xb01c0719, 0xe33e37e3), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xdf32e04c, 0x39d89b79, 0x618fc0fd, 0x44e9f60d, 0x94b90109), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xcf0c5d7f, 0x6e27a42b, 0xdd85b0d6, 0x85601580, 0x710ecab7), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xa1574565, 0x91efc8e9, 0x7a603f3f, 0x9970dfa2, 0x3a16d698), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardODEProblem}, OrdinaryDiffEqSDIRK.TRBDF2{0, ADTypes.AutoForwardDiff{nothing, ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}}, Nothing, OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, typeof(OrdinaryDiffEqCore.DEFAULT_PRECS), Val{:forward}(), true, nothing, typeof(OrdinaryDiffEqCore.trivial_limiter!)}, OrdinaryDiffEqCore.InterpolationData{SciMLBase.ODEFunction{true, true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x67957fcf, 0xde1396e6, 0xf3fda331, 0xb01c0719, 0xe33e37e3), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xdf32e04c, 0x39d89b79, 0x618fc0fd, 0x44e9f60d, 0x94b90109), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xcf0c5d7f, 0x6e27a42b, 0xdd85b0d6, 0x85601580, 0x710ecab7), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xa1574565, 0x91efc8e9, 0x7a603f3f, 0x9970dfa2, 0x3a16d698), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Vector{Vector{Float64}}, Vector{Float64}, Vector{Vector{Vector{Float64}}}, Nothing, cacheType, Nothing}, SciMLBase.DEStats, Nothing, Nothing, Nothing, Nothing}, Nothing, Nothing, Nothing} where cacheType<:(OrdinaryDiffEqSDIRK.TRBDF2Cache{Vector{Float64}, Vector{Float64}, Vector{Float64}, OrdinaryDiffEqSDIRK.TRBDF2Tableau{Float64, Float64}, N, typeof(OrdinaryDiffEqCore.trivial_limiter!)} where N<:(OrdinaryDiffEqNonlinearSolve.NLSolver{OrdinaryDiffEqNonlinearSolve.NLNewton{Rational{Int64}, Rational{Int64}, Rational{Int64}, Nothing}, true, Vector{Float64}, Float64, Nothing, Float64, OrdinaryDiffEqNonlinearSolve.NLNewtonCache{Vector{Float64}, Float64, Float64, Vector{Float64}, Matrix{Float64}, Matrix{Float64}, SciMLBase.UJacobianWrapper{true, SciMLBase.ODEFunction{true, true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x67957fcf, 0xde1396e6, 0xf3fda331, 0xb01c0719, 0xe33e37e3), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xdf32e04c, 0x39d89b79, 0x618fc0fd, 0x44e9f60d, 0x94b90109), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, SciMLBase.OverrideInitData{SciMLBase.NonlinearProblem{Nothing, true, ModelingToolkit.MTKParameters{Vector{Float64}, StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}, SciMLBase.NonlinearFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.GeneratedFunctionWrapper{(2, 2, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x9d3c64b8, 0x13b41e77, 0xa8ae653d, 0x405ef641, 0x4ad7000c), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x45393bcd, 0xb4bfed65, 0xcb080745, 0xadf81e6e, 0x169754fe), Nothing}}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, ModelingToolkit.ObservedFunctionCache{ModelingToolkit.System}, Nothing, ModelingToolkit.System, Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Nothing, @NamedTuple{}}, SciMLBase.StandardNonlinearProblem}, Nothing, Nothing, Nothing, ModelingToolkit.InitializationMetadata{ModelingToolkit.ReconstructInitializeprob{ModelingToolkit.var"#_getter#943"{Tuple{ComposedFunction{ModelingToolkit.PConstructorApplicator{typeof(identity)}, ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xcf0c5d7f, 0x6e27a42b, 0xdd85b0d6, 0x85601580, 0x710ecab7), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0xa1574565, 0x91efc8e9, 0x7a603f3f, 0x9970dfa2, 0x3a16d698), Nothing}}}}, Returns{StaticArraysCore.SizedVector{0, Float64, Vector{Float64}}}, Returns{Tuple{}}, Returns{Tuple{}}, Returns{Tuple{}}}}, ComposedFunction{typeof(identity), ModelingToolkit.ObservedWrapper{true, ModelingToolkit.GeneratedFunctionWrapper{(2, 3, true), RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x5bd2230c, 0xe07ff729, 0x156dfb47, 0xd0b5f2c0, 0x9b8b622e), Nothing}, RuntimeGeneratedFunctions.RuntimeGeneratedFunction{(:ˍ₋out, :__mtk_arg_1, :___mtkparameters___, :t), ModelingToolkit.var"#_RGF_ModTag", ModelingToolkit.var"#_RGF_ModTag", (0x8d20b3e9, 0x6c424c56, 0x93b7b6e1, 0xccbfe49a, 0xf2404181), Nothing}}}}}, Nothing, ModelingToolkit.SetInitialUnknowns{SymbolicIndexingInterface.MultipleSetters{Vector{SymbolicIndexingInterface.ParameterHookWrapper{SymbolicIndexingInterface.SetParameterIndex{ModelingToolkit.ParameterIndex{SciMLStructures.Initials, Int64}}, SymbolicUtils.BasicSymbolic{Real}}}}}}, Val{true}}, Nothing}, Float64, ModelingToolkit.MTKParameters{Vector{Float64}, Vector{Float64}, Tuple{}, Tuple{}, Tuple{}, Tuple{}}}, jcType, LinearSolve.LinearCache{Matrix{Float64}, Vector{Float64}, Vector{Float64}, SciMLBase.NullParameters, LinearSolve.DefaultLinearSolver, LinearSolve.DefaultLinearSolverInit{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, LinearAlgebra.QRCompactWY{Float64, Matrix{Float64}, Matrix{Float64}}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Vector{Int64}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Vector{Int64}}, Nothing, Nothing, Nothing, LinearAlgebra.SVD{Float64, Float64, Matrix{Float64}, Vector{Float64}}, LinearAlgebra.Cholesky{Float64, Matrix{Float64}}, LinearAlgebra.Cholesky{Float64, Matrix{Float64}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int32}}, Base.RefValue{Int32}}, Tuple{LinearAlgebra.LU{Float64, Matrix{Float64}, Vector{Int64}}, Base.RefValue{Int64}}, LinearAlgebra.QRPivoted{Float64, Matrix{Float64}, Vector{Float64}, Vector{Int64}}, Nothing, Nothing, Nothing, Nothing, Nothing}, LinearSolve.InvPreconditioner{LinearAlgebra.Diagonal{Float64, Vector{Float64}}}, LinearAlgebra.Diagonal{Float64, Vector{Float64}}, Float64, Bool, LinearSolve.LinearSolveAdjoint{Missing}}}, Float64} where jcType<:Tuple{DifferentiationInterfaceForwardDiffExt.ForwardDiffTwoArgJacobianPrep{Nothing, C, Tuple{}} where C<:(ForwardDiff.JacobianConfig{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A, <:Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A, Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A}} where _A), DifferentiationInterfaceForwardDiffExt.ForwardDiffTwoArgJacobianPrep{Nothing, C, Tuple{}} where C<:(ForwardDiff.JacobianConfig{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A, <:Tuple{Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A, Array{ForwardDiff.Dual{ForwardDiff.Tag{DiffEqBase.OrdinaryDiffEqTag, Float64}, Float64, _A}, 1} where _A}} where _A)}))}
QH2 vs turnover#
xs = qh2range
ys = [extract(qh2_g, sys_g.vNADHC1) extract(qh2_m, sys_m.vNADHC1) extract(qh2_q, sys_q.vNADHC1)]
plot(xs, ys, xlabel="QH2 (μM)", ylabel="NADH rate (mM/s)", label=["Gauthier" "Markevich" "Q site"]) |> PNG
QH2 vs ROS production#
xs = qh2range
ys = [extract(qh2_g, sys_g.vROSC1) extract(qh2_m, sys_m.vROSC1) extract(qh2_q, sys_q.vROSC1)]
plot(xs, ys, xlabel="QH2 (μM)", ylabel="ROS production", label=["Gauthier" "Markevich" "Q site"]) |> PNG
xs = qh2range
ys = stack(extract.(Ref(qh2_q), [sys_q.Q_C1, sys_q.SQ_C1, sys_q.QH2_C1, sys_q.I_C1]), dims=2)
pl1 = plot(xs, ys, xlabel="QH2 (μM)", ylabel="Concentration", label=["Q_C1" "SQ_C1" "QH2_C1" "I_C1"], title="Q site", legend=:top, ylims=(0, 17))
ys = stack(extract.(Ref(qh2_m), [sys_m.Q_C1, sys_m.SQ_C1, sys_m.QH2_C1, sys_m.Iq_C1]), dims=2)
pl2 = plot(xs, ys, xlabel="QH2 (μM)", ylabel="Concentration", label=["Q_C1" "SQ_C1" "QH2_C1" "I_C1"], title="Markevich", legend=:top, ylims=(0, 17))
plot(pl1, pl2) |> PNG
Gauthier model is sensitive to high QH2 because of slow NAD binding (k43).
@unpack C1_1, C1_3, C1_4, C1_5, C1_6, C1_7 = sys_g
xs = qh2range
ys = stack(extract.(Ref(qh2_g), [C1_3, C1_4]), dims=2) .* 1000
plot(xs, ys, xlabel="QH2 (μM)", ylabel="Conc (μM)", label=["C1_3" "C1_4"], lw=1.5) |> PNG
This notebook was generated using Literate.jl.